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    enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 562399, updated on 14-Feb-2019

    Summary

    Official Symbol
    enpp1provided by ZNC
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-172
    See related
    Ensembl:ENSDARG00000005789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:136238; si:ch211-142e24.2
    Orthologs

    Genomic context

    See enpp1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13403214..13521014)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13507257..13625034)
    103 previous assembly Zv9 (GCF_000002035.4) 20 NC_007131.5 (13317988..13435857)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886508 Neighboring gene protein phosphatase 2, regulatory subunit B', alpha isoform Neighboring gene potassium channel, subfamily K, member 3a Neighboring gene synaptotagmin-like 3 Neighboring gene ezrin b Neighboring gene radial spoke head 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC136238

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphodiesterase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic diphosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoside triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    Names
    dgf
    NP_001025339.1
    XP_005160498.1
    XP_009292877.1
    XP_021324146.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030168.1NP_001025339.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1

      Status: PROVISIONAL

      Source sequence(s)
      BX293547
      Conserved Domains (5) summary
      smart00201
      Location:112155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:177545
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:642860
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      13403214..13521014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294602.3XP_009292877.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

      Conserved Domains (4) summary
      pfam01033
      Location:70108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:137463
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:135503
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:602820
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    2. XM_005160441.4XP_005160498.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

      See identical proteins and their annotated locations for XP_005160498.1

      UniProtKB/TrEMBL
      B0JZL7
      Related
      ENSDARP00000112341.3, ENSDART00000127350.4
      Conserved Domains (5) summary
      smart00201
      Location:112155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:177545
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:644862
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    3. XM_021468471.1XP_021324146.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X3

      Conserved Domains (4) summary
      smart00201
      Location:112155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cl00089
      Location:644740
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
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