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    afdna afadin, adherens junction formation factor a [ Danio rerio (zebrafish) ]

    Gene ID: 558359, updated on 14-Feb-2019

    Summary

    Official Symbol
    afdnaprovided by ZNC
    Official Full Name
    afadin, adherens junction formation factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050419-52
    See related
    Ensembl:ENSDARG00000029472
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    mllt4; mllt4a; si:ch211-278j12.1
    Orthologs

    Genomic context

    See afdna in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (43122909..43346092, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (43225543..43456054, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 20 NC_007131.5 (43154672..43377831, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene monooxygenase, DBH-like 1, like Neighboring gene dual specificity phosphatase 23a Neighboring gene unc-93 homolog A Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 138

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    afadin
    Names
    MLLT4, super elongation complex subunit a
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4a
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4a

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      43122909..43346092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468687.1XP_021324362.1  afadin isoform X12

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    2. XM_021468679.1XP_021324354.1  afadin isoform X4

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    3. XM_021468684.1XP_021324359.1  afadin isoform X9

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    4. XM_021468678.1XP_021324353.1  afadin isoform X3

      Conserved Domains (5) summary
      cd00992
      Location:9831066
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:581910
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:412471
      FHA; FHA domain
      cl00155
      Location:19130
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15291695
      DUF4670; Domain of unknown function (DUF4670)
    5. XM_021468693.1XP_021324368.1  afadin isoform X17

      Related
      ENSDARP00000127130.1, ENSDART00000152888.3
      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9771060
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582904
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15191689
      DUF4670; Domain of unknown function (DUF4670)
    6. XM_021468688.1XP_021324363.1  afadin isoform X13

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261684
      DUF4670; Domain of unknown function (DUF4670)
    7. XM_021468685.1XP_021324360.1  afadin isoform X10

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261684
      DUF4670; Domain of unknown function (DUF4670)
    8. XM_021468677.1XP_021324352.1  afadin isoform X2

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15301695
      DUF4670; Domain of unknown function (DUF4670)
    9. XM_021468676.1XP_021324351.1  afadin isoform X1

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    10. XM_021468694.1XP_021324369.1  afadin isoform X18

      Conserved Domains (5) summary
      cd00992
      Location:9621045
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:567889
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:398457
      FHA; FHA domain
      cl00155
      Location:19130
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15041662
      DUF4670; Domain of unknown function (DUF4670)
    11. XM_021468691.1XP_021324366.1  afadin isoform X15

      Conserved Domains (5) summary
      cd00992
      Location:9761059
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:581903
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:412471
      FHA; FHA domain
      cl00155
      Location:19130
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15181676
      DUF4670; Domain of unknown function (DUF4670)
    12. XM_021468695.1XP_021324370.1  afadin isoform X19

      Conserved Domains (5) summary
      cd00992
      Location:9761059
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:581903
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:412471
      FHA; FHA domain
      cl00155
      Location:19130
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15221688
      DUF4670; Domain of unknown function (DUF4670)
    13. XM_021468692.1XP_021324367.1  afadin isoform X16

      Conserved Domains (5) summary
      cd00992
      Location:9831066
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:581910
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:412471
      FHA; FHA domain
      cl00155
      Location:19130
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15251683
      DUF4670; Domain of unknown function (DUF4670)
    14. XM_021468682.1XP_021324357.1  afadin isoform X7

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9701053
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:568897
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:399458
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15121682
      DUF4670; Domain of unknown function (DUF4670)
    15. XM_021468680.1XP_021324355.1  afadin isoform X5

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9771060
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582904
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15231689
      DUF4670; Domain of unknown function (DUF4670)
    16. XM_021468686.1XP_021324361.1  afadin isoform X11

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    17. XM_021468683.1XP_021324358.1  afadin isoform X8

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261696
      DUF4670; Domain of unknown function (DUF4670)
    18. XM_021468681.1XP_021324356.1  afadin isoform X6

      Related
      ENSDARP00000111104.2, ENSDART00000126343.3
      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261684
      DUF4670; Domain of unknown function (DUF4670)
    19. XM_021468690.1XP_021324365.1  afadin isoform X14

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261651
      DUF4670; Domain of unknown function (DUF4670)
    20. XM_021468689.1XP_021324364.1  afadin isoform X14

      Conserved Domains (6) summary
      cd01782
      Location:19131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00992
      Location:9841067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:582911
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00498
      Location:413472
      FHA; FHA domain
      cl00155
      Location:245338
      UBQ; Ubiquitin-like proteins
      cl25548
      Location:15261651
      DUF4670; Domain of unknown function (DUF4670)
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