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    Arc activity-regulated cytoskeleton-associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54323, updated on 12-Mar-2019

    Summary

    Official Symbol
    Arcprovided by RGD
    Official Full Name
    activity-regulated cytoskeleton-associated proteinprovided by RGD
    Primary source
    RGD:62037
    See related
    Ensembl:ENSRNOG00000043465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rg3.1
    Summary
    may play a role in neuronal plasticity, long-term potentiation, and memory consolidation [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 60.4), Thymus (RPKM 24.8) and 5 other tissues See more
    Orthologs

    Genomic context

    See Arc in Genome Data Viewer
    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (115907097..115911059, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (115812499..115815958, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550505 Neighboring gene uncharacterized LOC102550355 Neighboring gene maestro heat-like repeat family member 4 Neighboring gene uncharacterized LOC103692938 Neighboring gene Jrk helix-turn-helix protein Neighboring gene thioesterase superfamily member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Serotonin and anxiety, organism-specific biosystem (from WikiPathways)
      Serotonin and anxiety, organism-specific biosystem
      Serotonin and anxiety

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    learning IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of dendritic spine morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of neuronal synaptic plasticity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated intercellular transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic endosome EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynaptic endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activity-regulated cytoskeleton-associated protein
    Names
    ARC/ARG3.1
    activity regulated cytoskeletal-associated protein
    activity-regulated gene 3.1 protein
    arg3.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019361.1NP_062234.1  activity-regulated cytoskeleton-associated protein

      See identical proteins and their annotated locations for NP_062234.1

      Status: PROVISIONAL

      Source sequence(s)
      U19866
      UniProtKB/Swiss-Prot
      Q63053
      Related
      ENSRNOP00000063719.1, ENSRNOT00000067442.1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      115907097..115911059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595064.1XP_017450553.1  activity-regulated cytoskeleton-associated protein isoform X1

      UniProtKB/Swiss-Prot
      Q63053
      Related
      ENSRNOP00000068090.1, ENSRNOT00000076998.2

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      102957256..102960700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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