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    HEY2 hes related family bHLH transcription factor with YRPW motif 2 [ Bos taurus (cattle) ]

    Gene ID: 538619, updated on 14-Jan-2019

    Summary

    Official Symbol
    HEY2provided by VGNC
    Official Full Name
    hes related family bHLH transcription factor with YRPW motif 2provided by VGNC
    Primary source
    VGNC:VGNC:29829
    See related
    BGD:BT14818; Ensembl:ENSBTAG00000000919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See HEY2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 9 NC_037336.1 (25546012..25561094, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 9 AC_000166.1 (25873435..25884617, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene microRNA mir-2477 Neighboring gene HD domain containing 2

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
      Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...

    General gene information

    Homology

    General protein information

    Preferred Names
    hairy/enhancer-of-split related with YRPW motif protein 2
    Names
    hairy/enhancer-of-split related with YRPW motif 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192055.1NP_001178984.1  hairy/enhancer-of-split related with YRPW motif protein 2

      See identical proteins and their annotated locations for NP_001178984.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000009
      UniProtKB/TrEMBL
      E1BEV8
      Related
      ENSBTAP00000001214.3, ENSBTAT00000001214.4
      Conserved Domains (2) summary
      cd00083
      Location:49105
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:121162
      Hairy_orange; Hairy Orange

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      25546012..25561094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996775.1XP_024852543.1  hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1

      Conserved Domains (2) summary
      smart00511
      Location:142188
      ORANGE; Orange domain
      cd00083
      Location:72128
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    2. XM_024996776.1XP_024852544.1  hairy/enhancer-of-split related with YRPW motif protein 2 isoform X2

      Conserved Domains (2) summary
      smart00511
      Location:73119
      ORANGE; Orange domain
      cd00083
      Location:359
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
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