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    F2R coagulation factor II thrombin receptor [ Bos taurus (cattle) ]

    Gene ID: 526585, updated on 22-Feb-2019

    Summary

    Official Symbol
    F2Rprovided by VGNC
    Official Full Name
    coagulation factor II thrombin receptorprovided by VGNC
    Primary source
    VGNC:VGNC:28683
    See related
    BGD:BT23461; Ensembl:ENSBTAG00000020199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PAR1
    Orthologs

    Genomic context

    See F2R in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 10 NC_037337.1 (7945220..7963559)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 10 AC_000167.1 (7879496..7897151)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904831 Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene coiled-coil domain-containing protein 58-like Neighboring gene F2R like trypsin receptor 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • MGC152489

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein beta-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    thrombin-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPKK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    connective tissue replacement involved in inflammatory response wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of synaptic specificity at neuromuscular junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    homeostasis of number of cells within a tissue ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of renin secretion into blood stream ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of blood coagulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of collagen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-6 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-8 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    thrombin-activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet dense tubular network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteinase-activated receptor 1
    Names
    PAR-1
    protease-activated receptor 1
    thrombin receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103097.2NP_001096567.1  proteinase-activated receptor 1 precursor

      See identical proteins and their annotated locations for NP_001096567.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151272
      UniProtKB/Swiss-Prot
      A7YY44
      Related
      ENSBTAP00000026902.4, ENSBTAT00000026902.5
      Conserved Domains (1) summary
      pfam00001
      Location:122373
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      7945220..7963559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997572.1XP_024853340.1  proteinase-activated receptor 1 isoform X1

      Conserved Domains (2) summary
      cd15369
      Location:1738
      7tmA_PAR1; TM helix 2 [structural motif]
      cl28897
      Location:1261
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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