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    SMAD2 SMAD family member 2 [ Bos taurus (cattle) ]

    Gene ID: 516010, updated on 14-Jan-2019

    Summary

    Official Symbol
    SMAD2provided by VGNC
    Official Full Name
    SMAD family member 2provided by VGNC
    Primary source
    VGNC:VGNC:34975
    See related
    BGD:BT19091; Ensembl:ENSBTAG00000039916
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See SMAD2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 24 NC_037351.1 (47492682..47583346, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 24 AC_000181.1 (47963393..48022086, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444197 Neighboring gene uncharacterized LOC112444163 Neighboring gene uncharacterized LOC101904605 Neighboring gene uncharacterized LOC104969950 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC112444201

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 2
    Names
    MAD homolog 2
    SMAD 2
    SMAD, mothers against DPP homolog 2
    mothers against DPP homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046218.1NP_001039683.1  mothers against decapentaplegic homolog 2

      See identical proteins and their annotated locations for NP_001039683.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ432067
      UniProtKB/Swiss-Prot
      Q1W668
      Related
      ENSBTAP00000017649.4, ENSBTAT00000017649.5
      Conserved Domains (2) summary
      cd10491
      Location:8172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      47492682..47583346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984266.1XP_024840034.1  mothers against decapentaplegic homolog 2 isoform X2

      Conserved Domains (2) summary
      cd10491
      Location:8142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    2. XM_024984264.1XP_024840032.1  mothers against decapentaplegic homolog 2 isoform X1

      Related
      ENSBTAP00000069385.1, ENSBTAT00000085974.1
      Conserved Domains (2) summary
      cd10491
      Location:8172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    3. XM_024984265.1XP_024840033.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    4. XM_024984267.1XP_024840035.1  mothers against decapentaplegic homolog 2 isoform X2

      Related
      ENSBTAP00000036451.4, ENSBTAT00000036594.5
      Conserved Domains (2) summary
      cd10491
      Location:8142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
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