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    RAB6B RAB6B, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 51560, updated on 12-May-2019

    Summary

    Official Symbol
    RAB6Bprovided by HGNC
    Official Full Name
    RAB6B, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:14902
    See related
    Ensembl:ENSG00000154917 MIM:615852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in brain (RPKM 76.4), heart (RPKM 6.6) and 1 other tissue See more
    Orthologs

    Genomic context

    See RAB6B in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (133824235..133895847, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133543079..133614691, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene acyl-CoA synthetase long chain family member 3 pseudogene Neighboring gene uncharacterized LOC105374116 Neighboring gene SRP receptor subunit beta Neighboring gene chromosome 3 open reading frame 36 Neighboring gene solute carrier organic anion transporter family member 2A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
      RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
    • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
      RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
    • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
      Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    myosin V binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi apparatus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-6B
    Names
    small GTP-binding protein
    small GTPase RAB6B
    NP_057661.3
    XP_011511195.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363953.1NP_001350882.1  ras-related protein Rab-6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC080128, AF166492, AK295451, BC078662, DA221889
      Consensus CDS
      CCDS87137.1
      Conserved Domains (1) summary
      cd01861
      Location:11161
      Rab6; Rab GTPase family 6 (Rab6)
    2. NM_016577.4NP_057661.3  ras-related protein Rab-6B isoform 1

      See identical proteins and their annotated locations for NP_057661.3

      Status: VALIDATED

      Source sequence(s)
      AC080128, AF166492, DA221889
      Consensus CDS
      CCDS3082.1
      UniProtKB/Swiss-Prot
      Q9NRW1
      Related
      ENSP00000285208.4, ENST00000285208.9
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      133824235..133895847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512893.2XP_011511195.1  ras-related protein Rab-6B isoform X1

      UniProtKB/Swiss-Prot
      Q9NRW1
      Related
      ENSP00000419381.1, ENST00000486858.5
      Conserved Domains (1) summary
      cd01861
      Location:11161
      Rab6; Rab GTPase family 6 (Rab6)
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