Format

Send to:

Choose Destination
    • Showing Current items.

    ITGB4 integrin subunit beta 4 [ Bos taurus (cattle) ]

    Gene ID: 506995, updated on 14-Jan-2019

    Summary

    Official Symbol
    ITGB4provided by VGNC
    Official Full Name
    integrin subunit beta 4provided by VGNC
    Primary source
    VGNC:VGNC:30329
    See related
    BGD:BT11873; Ensembl:ENSBTAG00000018169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See ITGB4 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 19 NC_037346.1 (55840150..55872542, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 19 AC_000176.1 (56472336..56506801, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene H3 histone, family 3B Neighboring gene galactokinase 1 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene SAP30 binding protein Neighboring gene RecQ like helicase 5 Neighboring gene small integral membrane protein 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    General gene information

    Homology

    General protein information

    Preferred Names
    integrin beta-4
    Names
    integrin, beta 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193257.2NP_001180186.2  integrin beta-4 precursor

      Status: VALIDATED

      Source sequence(s)
      AAFC03054511, AAFC03117429, AAFC03129054, EH177871
      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:12211314
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14611541
      fn3; Fibronectin type III domain
      pfam00362
      Location:37454
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:627710
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:544574
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      55840150..55872542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979798.1XP_024835566.1  integrin beta-4 isoform X4

      Related
      ENSBTAP00000040201.4, ENSBTAT00000042566.4
      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:14581548
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544574
      EGF_2; EGF-like domain
      pfam00041
      Location:15721657
      fn3; Fibronectin type III domain
      pfam07965
      Location:627710
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:37454
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_024979795.1XP_024835563.1  integrin beta-4 isoform X1

      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15741664
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544574
      EGF_2; EGF-like domain
      pfam00041
      Location:16881773
      fn3; Fibronectin type III domain
      pfam07965
      Location:627710
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:37454
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. XM_024979796.1XP_024835564.1  integrin beta-4 isoform X2

      Related
      ENSBTAP00000074469.1, ENSBTAT00000075471.1
      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15211611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544574
      EGF_2; EGF-like domain
      pfam00041
      Location:16351720
      fn3; Fibronectin type III domain
      pfam07965
      Location:627710
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:37454
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. XM_024979797.1XP_024835565.1  integrin beta-4 isoform X3

      Related
      ENSBTAP00000065111.1, ENSBTAT00000079531.1
      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15111601
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544574
      EGF_2; EGF-like domain
      pfam00041
      Location:16251710
      fn3; Fibronectin type III domain
      pfam07965
      Location:627710
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:37454
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Support Center