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    Ptpro protein tyrosine phosphatase, receptor type, O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50677, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ptproprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Oprovided by RGD
    Primary source
    RGD:62068
    See related
    Ensembl:ENSRNOG00000006231
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLEPP1; RPTP-BK
    Summary
    may regulate glomerular epithelial cell function; may play a role in neural cell development [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Kidney (RPKM 130.6), Brain (RPKM 85.8) and 8 other tissues See more
    Orthologs

    Genomic context

    See Ptpro in Genome Data Viewer
    Location:
    4q43-q44
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (171250766..171461571)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (235507823..235718691)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene prohibitin-like Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene serine/threonine kinase receptor associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt-protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular visceral epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    glomerular visceral epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    glomerulus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    monocyte chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    slit diaphragm assembly ISO
    Inferred from Sequence Orthology
    more info
     
    slit diaphragm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase O
    Names
    Glomerular epithelial protein 1
    receptor-type protein tyrosine phosphatase D30
    NP_059032.1
    XP_006237633.1
    XP_006237634.1
    XP_017448340.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017336.1NP_059032.1  receptor-type tyrosine-protein phosphatase O precursor

      See identical proteins and their annotated locations for NP_059032.1

      Status: PROVISIONAL

      Source sequence(s)
      U28938
      UniProtKB/TrEMBL
      Q62797
      Related
      ENSRNOP00000044055.1, ENSRNOT00000040576.3
      Conserved Domains (4) summary
      smart00194
      Location:9371192
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9651193
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:434526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:725805
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      171250766..171461571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592851.1XP_017448340.1  receptor-type tyrosine-protein phosphatase O isoform X1

    2. XM_006237571.3XP_006237633.1  receptor-type tyrosine-protein phosphatase O isoform X2

      Conserved Domains (2) summary
      smart00194
      Location:126381
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:154382
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_006237572.3XP_006237634.1  receptor-type tyrosine-protein phosphatase O isoform X3

      Conserved Domains (2) summary
      smart00194
      Location:98353
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:126354
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      158744680..158954298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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