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    Sh2d1a SH2 domain containing 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501502, updated on 18-Apr-2019

    Summary

    Official Symbol
    Sh2d1aprovided by RGD
    Official Full Name
    SH2 domain containing 1Aprovided by RGD
    Primary source
    RGD:1562408
    See related
    Ensembl:ENSRNOG00000006263
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562408
    Expression
    Biased expression in Thymus (RPKM 381.6), Spleen (RPKM 89.8) and 2 other tissues See more
    Orthologs

    Genomic context

    See Sh2d1a in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128897053..128925408)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (128978818..129007045)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene similar to actin alpha 1 skeletal muscle protein Neighboring gene estrogen receptor binding site associated antigen 9-like Neighboring gene teneurin-1-like Neighboring gene teneurin transmembrane protein 1 Neighboring gene teneurin transmembrane protein 1 Neighboring gene 60S ribosomal protein L23 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular defense response IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    SH2 domain-containing protein 1A
    Names
    SH2 domain protein 1A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109313.2NP_001102783.2  SH2 domain-containing protein 1A

      See identical proteins and their annotated locations for NP_001102783.2

      Status: PROVISIONAL

      Source sequence(s)
      BC167036
      UniProtKB/Swiss-Prot
      B2RZ59
      Related
      ENSRNOP00000008444.4, ENSRNOT00000008444.4
      Conserved Domains (1) summary
      cd10400
      Location:2104
      SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      128897053..128925408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773527.2XP_008771749.1  SH2 domain-containing protein 1A isoform X1

      Conserved Domains (1) summary
      cd10400
      Location:2104
      SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a
    2. XM_008773528.2XP_008771750.1  SH2 domain-containing protein 1A isoform X2

      See identical proteins and their annotated locations for XP_008771750.1

      UniProtKB/Swiss-Prot
      B2RZ59
      Conserved Domains (1) summary
      cd10400
      Location:2104
      SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      120486695..120514918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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