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    OAZ1 ornithine decarboxylase antizyme 1 [ Homo sapiens (human) ]

    Gene ID: 4946, updated on 21-Apr-2019

    Summary

    Official Symbol
    OAZ1provided by HGNC
    Official Full Name
    ornithine decarboxylase antizyme 1provided by HGNC
    Primary source
    HGNC:HGNC:8095
    See related
    Ensembl:ENSG00000104904 MIM:601579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AZ1; AZI; OAZ
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 404.8), lymph node (RPKM 286.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See OAZ1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (2269486..2273488)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2269520..2273487)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene uncharacterized LOC105372240 Neighboring gene PEAK family member 3 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene uncharacterized LOC101928572

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
      Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
    • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
      Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
    • Nucleotide Metabolism, organism-specific biosystem (from WikiPathways)
      Nucleotide Metabolism, organism-specific biosystemThe pathway outlined above focuses on purine metabolism and in particular that of guanine metabolism.
    • Regulation of ornithine decarboxylase (ODC), organism-specific biosystem (from REACTOME)
      Regulation of ornithine decarboxylase (ODC), organism-specific biosystemPolyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138338

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ornithine decarboxylase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cellular amino acid metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 1
    Names
    ODC-Az
    antizyme 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301020.1NP_001287949.1  ornithine decarboxylase antizyme 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1.
      Source sequence(s)
      BC100291, BM423450, HY050868
      Consensus CDS
      CCDS77214.1
      UniProtKB/TrEMBL
      J3QQY4
      Related
      ENSP00000463955.3, ENST00000582888.8
      Conserved Domains (1) summary
      pfam02100
      Location:136215
      ODC_AZ; Ornithine decarboxylase antizyme
    2. NM_004152.3NP_004143.1  ornithine decarboxylase antizyme 1 isoform 1

      See identical proteins and their annotated locations for NP_004143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC100291, HY050868
      Consensus CDS
      CCDS58639.1
      UniProtKB/Swiss-Prot
      P54368
      Related
      ENSP00000473381.1, ENST00000602676.6
      Conserved Domains (1) summary
      pfam02100
      Location:138217
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      2269486..2273488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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