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    KLK8 kallikrein related peptidase 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 484352, updated on 26-Sep-2018

    Summary

    Gene symbol
    KLK8
    Gene description
    kallikrein related peptidase 8
    See related
    Ensembl:ENSCAFG00000002896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis

    Genomic context

    See KLK8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 1 NC_006583.3 (105874788..105880788)

    Chromosome 1 - NC_006583.3Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 10 Neighboring gene kallikrein related peptidase 9 Neighboring gene kallikrein related peptidase 7 Neighboring gene kallikrein related peptidase 6

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006583.3 Chromosome 1 Reference CanFam3.1 Primary Assembly

    General gene information

    Homology

    General protein information

    Preferred Names
    kallikrein-8
    NP_001184091.1
    NP_001184092.1
    XP_005615819.1
    XP_013969767.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197162.1NP_001184091.1  kallikrein-8 isoform a precursor

      See identical proteins and their annotated locations for NP_001184091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      HM135456
      UniProtKB/TrEMBL
      E2FGH8
      Related
      ENSCAFP00000004284.2, ENSCAFT00000004630.3
      Conserved Domains (1) summary
      smart00020
      Location:32251
      Tryp_SPc; Trypsin-like serine protease
    2. NM_001197163.1NP_001184092.1  kallikrein-8 isoform b precursor

      See identical proteins and their annotated locations for NP_001184092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      HM135457
      UniProtKB/TrEMBL
      E2FGH9
      Related
      ENSCAFP00000033471.2, ENSCAFT00000037845.2
      Conserved Domains (2) summary
      smart00020
      Location:32166
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:33166
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006583.3 Reference CanFam3.1 Primary Assembly

      Range
      105874788..105880788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005615762.2XP_005615819.1  kallikrein-8 isoform X1

      See identical proteins and their annotated locations for XP_005615819.1

      UniProtKB/TrEMBL
      E2FGH8
      Conserved Domains (1) summary
      smart00020
      Location:32251
      Tryp_SPc; Trypsin-like serine protease
    2. XM_014114292.2XP_013969767.1  kallikrein-8 isoform X1

      UniProtKB/TrEMBL
      E2FGH8
      Conserved Domains (1) summary
      smart00020
      Location:32251
      Tryp_SPc; Trypsin-like serine protease
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