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    Hcst hematopoietic cell signal transducer [ Rattus norvegicus (Norway rat) ]

    Gene ID: 474146, updated on 18-Apr-2019

    Summary

    Official Symbol
    Hcstprovided by RGD
    Official Full Name
    hematopoietic cell signal transducerprovided by RGD
    Primary source
    RGD:1359238
    See related
    Ensembl:ENSRNOG00000020849
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dap10
    Expression
    Biased expression in Spleen (RPKM 41.5), Thymus (RPKM 34.6) and 7 other tissues See more
    Orthologs

    Genomic context

    See Hcst in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88879425..88881653, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (90035099..90037271, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene similar to actin, gamma 2, smooth muscle, enteric Neighboring gene Tyro protein tyrosine kinase binding protein Neighboring gene NFKB inhibitor delta Neighboring gene amyloid beta precursor like protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    phosphatidylinositol 3-kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hematopoietic cell signal transducer
    Names
    DNAX-activation protein 10
    membrane protein DAP10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005900.1NP_001005900.1  hematopoietic cell signal transducer precursor

      See identical proteins and their annotated locations for NP_001005900.1

      Status: PROVISIONAL

      Source sequence(s)
      AY247020
      UniProtKB/Swiss-Prot
      Q6X9T8
      Related
      ENSRNOP00000028287.4, ENSRNOT00000028287.4
      Conserved Domains (1) summary
      pfam07213
      Location:179
      DAP10; DAP10 membrane protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      88879425..88881653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228785.3XP_006228847.1  hematopoietic cell signal transducer isoform X1

      Conserved Domains (1) summary
      pfam07213
      Location:178
      DAP10; DAP10 membrane protein

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      80049152..80051187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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