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    GRIA4 glutamate ionotropic receptor AMPA type subunit 4 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 466768, updated on 14-Feb-2019

    Summary

    Official Symbol
    GRIA4provided by VGNC
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 4provided by VGNC
    Primary source
    VGNC:VGNC:11793
    Locus tag
    CK820_G0031111
    See related
    Ensembl:ENSPTRG00000004233
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See GRIA4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 11 NC_036890.1 (101388490..101763635)
    104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 11 NC_006478.4 (105832301..106219125)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 11 NC_006478.3 (103422949..103805092)

    Chromosome 11 - NC_036890.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain-containing protein 17 Neighboring gene uncharacterized LOC107967201 Neighboring gene 60 kDa heat shock protein, mitochondrial pseudogene Neighboring gene U4 spliceosomal RNA Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene kelch repeat and BTB domain containing 3 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nicotine addiction, organism-specific biosystem (from KEGG)
      Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Nicotine addiction, conserved biosystem (from KEGG)
      Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    glutamate receptor 4
    Names
    glutamate receptor, ionotrophic, AMPA 4
    glutamate receptor, ionotropic, AMPA 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036890.1 Reference Clint_PTRv2 Primary Assembly

      Range
      101388490..101763635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016921901.2XP_016777390.1  glutamate receptor 4 isoform X1

      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:546825
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region
    2. XM_016921904.2XP_016777393.1  glutamate receptor 4 isoform X4

      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:546825
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region
    3. XM_016921905.2XP_016777394.1  glutamate receptor 4 isoform X3

      Conserved Domains (2) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    4. XM_016921907.2XP_016777396.1  glutamate receptor 4 isoform X5

      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      pfam00060
      Location:546766
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414765
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    5. XM_016921909.1XP_016777398.1  glutamate receptor 4 isoform X6

      Related
      ENSPTRP00000085221.1, ENSPTRT00000078536.1
      Conserved Domains (1) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    6. XM_016921903.2XP_016777392.1  glutamate receptor 4 isoform X3

      Conserved Domains (2) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    7. XM_016921902.2XP_016777391.1  glutamate receptor 4 isoform X2

      UniProtKB/TrEMBL
      C7G3L3
      Related
      ENSPTRP00000007287.4
      Conserved Domains (2) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    8. XM_016921906.2XP_016777395.1  glutamate receptor 4 isoform X1

      Related
      ENSPTRP00000083883.1
      Conserved Domains (4) summary
      cd06388
      Location:28398
      PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
      cd13727
      Location:414795
      PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:546825
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39380
      ANF_receptor; Receptor family ligand binding region

    RNA

    1. XR_001707527.2 RNA Sequence

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