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    MECOM MDS1 and EVI1 complex locus [ Pan troglodytes (chimpanzee) ]

    Gene ID: 460837, updated on 20-Apr-2019

    Summary

    Official Symbol
    MECOMprovided by VGNC
    Official Full Name
    MDS1 and EVI1 complex locusprovided by VGNC
    Primary source
    VGNC:VGNC:2041
    Locus tag
    CK820_G0006115
    See related
    Ensembl:ENSPTRG00000015601
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    EVI1
    Orthologs

    Genomic context

    See MECOM in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 3 NC_036882.1 (167119944..167700322, complement)
    104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 3 NC_006490.4 (172768150..173348719, complement)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 3 NC_006490.3 (172904698..173204651, complement)

    Chromosome 3 - NC_036882.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104005843 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene uncharacterized LOC112208681 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    MDS1 and EVI1 complex locus protein EVI1
    Names
    ecotropic viral integration site 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036882.1 Reference Clint_PTRv2 Primary Assembly

      Range
      167119944..167700322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016942279.2XP_016797768.1  MDS1 and EVI1 complex locus protein EVI1 isoform X11

    2. XM_016942278.2XP_016797767.1  MDS1 and EVI1 complex locus protein EVI1 isoform X10

    3. XM_016942277.2XP_016797766.1  MDS1 and EVI1 complex locus protein EVI1 isoform X9

    4. XM_009446818.3XP_009445093.2  MDS1 and EVI1 complex locus protein EVI1 isoform X1

    5. XM_016942276.1XP_016797765.1  MDS1 and EVI1 complex locus protein EVI1 isoform X4

      Related
      ENSPTRP00000067520.1, ENSPTRT00000106272.1
      Conserved Domains (6) summary
      PHA00733
      Location:845964
      PHA00733; hypothetical protein
      smart00317
      Location:80196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5189
      Location:302395
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:914934
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:926950
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:351435
      zf-C2H2_8; C2H2-type zinc ribbon
    6. XM_009446825.2XP_009445100.1  MDS1 and EVI1 complex locus protein EVI1 isoform X7

      See identical proteins and their annotated locations for XP_009445100.1

      UniProtKB/TrEMBL
      H2QNP7
      Related
      ENSPTRP00000080399.1, ENSPTRT00000089523.1
      Conserved Domains (6) summary
      PHA00733
      Location:689785
      PHA00733; hypothetical protein
      COG5189
      Location:114207
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:735755
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:733755
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:747771
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:163247
      zf-C2H2_8; C2H2-type zinc ribbon
    7. XM_009446824.2XP_009445099.1  MDS1 and EVI1 complex locus protein EVI1 isoform X6

      See identical proteins and their annotated locations for XP_009445099.1

      Conserved Domains (5) summary
      PHA00733
      Location:690786
      PHA00733; hypothetical protein
      sd00017
      Location:736756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:734756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748772
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:164248
      zf-C2H2_8; C2H2-type zinc ribbon
    8. XM_003310090.5XP_003310138.1  MDS1 and EVI1 complex locus protein EVI1 isoform X7

      See identical proteins and their annotated locations for XP_003310138.1

      UniProtKB/TrEMBL
      H2QNP7
      Conserved Domains (6) summary
      PHA00733
      Location:689785
      PHA00733; hypothetical protein
      COG5189
      Location:114207
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:735755
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:733755
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:747771
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:163247
      zf-C2H2_8; C2H2-type zinc ribbon
    9. XM_009446823.3XP_009445098.1  MDS1 and EVI1 complex locus protein EVI1 isoform X6

      See identical proteins and their annotated locations for XP_009445098.1

      Conserved Domains (5) summary
      PHA00733
      Location:690786
      PHA00733; hypothetical protein
      sd00017
      Location:736756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:734756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748772
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:164248
      zf-C2H2_8; C2H2-type zinc ribbon
    10. XM_009446822.2XP_009445097.1  MDS1 and EVI1 complex locus protein EVI1 isoform X5

      Related
      ENSPTRP00000067903.1, ENSPTRT00000105943.1
      Conserved Domains (6) summary
      PHA00733
      Location:754850
      PHA00733; hypothetical protein
      smart00317
      Location:872
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:800820
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:798820
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:812836
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:228312
      zf-C2H2_8; C2H2-type zinc ribbon
    11. XM_009446819.3XP_009445094.2  MDS1 and EVI1 complex locus protein EVI1 isoform X2

      UniProtKB/TrEMBL
      K7B2V2
    12. XM_009446820.3XP_009445095.2  MDS1 and EVI1 complex locus protein EVI1 isoform X3

    13. XM_516864.5XP_516864.3  MDS1 and EVI1 complex locus protein EVI1 isoform X8

      Related
      ENSPTRP00000026847.4, ENSPTRT00000029094.4
      Conserved Domains (5) summary
      PHA00733
      Location:657776
      PHA00733; hypothetical protein
      COG5189
      Location:114207
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:726746
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:738762
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:163247
      zf-C2H2_8; C2H2-type zinc ribbon
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