Format

Send to:

Choose Destination
    • Showing Current items.

    ITGB4 integrin subunit beta 4 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 454887, updated on 14-Feb-2019

    Summary

    Official Symbol
    ITGB4provided by VGNC
    Official Full Name
    integrin subunit beta 4provided by VGNC
    Primary source
    VGNC:VGNC:9339
    Locus tag
    CK820_G0039877
    See related
    Ensembl:ENSPTRG00000009653
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See ITGB4 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 17 NC_036896.1 (68833324..68869865)
    104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 17 NC_006484.4 (75279730..75316452)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 17 NC_006484.3 (74672798..74710506)

    Chromosome 17 - NC_036896.1Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 5 Neighboring gene small integral membrane protein 6 Neighboring gene SAP30 binding protein Neighboring gene galactokinase 1 Neighboring gene H3 histone family member 3B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    integrin beta-4
    Names
    integrin, beta 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036896.1 Reference Clint_PTRv2 Primary Assembly

      Range
      68833324..68869865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016930890.2XP_016786379.1  integrin beta-4 isoform X1

    2. XM_016930891.2XP_016786380.1  integrin beta-4 isoform X2

      Related
      ENSPTRP00000082546.1
      Conserved Domains (6) summary
      smart00187
      Location:37453
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:15281609
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
      pfam00041
      Location:16421727
      fn3; Fibronectin type III domain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
    3. XM_016930892.2XP_016786381.1  integrin beta-4 isoform X3

      Related
      ENSPTRP00000016404.4
      Conserved Domains (6) summary
      smart00187
      Location:37453
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:15111592
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
      pfam00041
      Location:16251710
      fn3; Fibronectin type III domain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
    4. XM_016930893.2XP_016786382.1  integrin beta-4 isoform X4

      Related
      ENSPTRP00000064945.1
      Conserved Domains (6) summary
      smart00187
      Location:37453
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:14581539
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
      pfam00041
      Location:15721657
      fn3; Fibronectin type III domain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
    5. XM_016930894.2XP_016786383.1  integrin beta-4 isoform X1

    Support Center