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    MST1 macrophage stimulating 1 [ Homo sapiens (human) ]

    Gene ID: 4485, updated on 21-Apr-2019

    Summary

    Official Symbol
    MST1provided by HGNC
    Official Full Name
    macrophage stimulating 1provided by HGNC
    Primary source
    HGNC:HGNC:7380
    See related
    Ensembl:ENSG00000173531 MIM:142408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSP; HGFL; NF15S2; D3F15S2; DNF15S2
    Summary
    The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
    Annotation information
    Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
    Expression
    Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues See more
    Orthologs

    Genomic context

    See MST1 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (49683947..49689523, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49721380..49726196, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bassoon presynaptic cytomatrix protein Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene GDP-mannose pyrophosphorylase B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    NHGRI GWA Catalog
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    NHGRI GWA Catalog
    Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog
    Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    hepatocyte growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hepatocyte growth factor-like protein
    Names
    hepatocyte growth factor-like protein homolog
    macrophage stimulating 1 (hepatocyte growth factor-like)
    macrophage-stimulating protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016454.1 RefSeqGene

      Range
      5001..9817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020998.3NP_066278.3  hepatocyte growth factor-like protein precursor

      See identical proteins and their annotated locations for NP_066278.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AK222893, BM672747, DC315638, L11924
      Consensus CDS
      CCDS33757.2
      UniProtKB/Swiss-Prot
      P26927
      UniProtKB/TrEMBL
      G3XAK1, Q53GN8
      Related
      ENSP00000414287.2, ENST00000449682.2
      Conserved Domains (5) summary
      smart00020
      Location:497718
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:382464
      KR; Kringle domain
      cd00190
      Location:498721
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00024
      Location:39117
      PAN_1; PAN domain
      pfam00051
      Location:297375
      Kringle; Kringle domain

    RNA

    1. NR_146060.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has several difference in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC099668

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      49683947..49689523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713166.2XP_006713229.1  hepatocyte growth factor-like protein isoform X5

      Conserved Domains (4) summary
      smart00020
      Location:452673
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:338419
      KR; Kringle domain
      cd00190
      Location:453676
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00024
      Location:39117
      PAN_1; PAN domain
    2. XM_017006461.2XP_016861950.1  hepatocyte growth factor-like protein isoform X3

    3. XM_017006463.2XP_016861952.1  hepatocyte growth factor-like protein isoform X6

    4. XM_017006460.2XP_016861949.1  hepatocyte growth factor-like protein isoform X2

    5. XM_011533732.2XP_011532034.1  hepatocyte growth factor-like protein isoform X1

      Conserved Domains (5) summary
      smart00020
      Location:527730
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:122202
      KR; Kringle domain
      cd00190
      Location:527733
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:37118
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      cl00100
      Location:202241
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    6. XM_017006464.2XP_016861953.1  hepatocyte growth factor-like protein isoform X7

    7. XM_017006462.2XP_016861951.1  hepatocyte growth factor-like protein isoform X4

    8. XM_017006465.2XP_016861954.1  hepatocyte growth factor-like protein isoform X8

    9. XM_017006467.2XP_016861956.1  hepatocyte growth factor-like protein isoform X10

    10. XM_017006466.2XP_016861955.1  hepatocyte growth factor-like protein isoform X9

    11. XM_011533738.3XP_011532040.1  hepatocyte growth factor-like protein isoform X11

      Conserved Domains (3) summary
      smart00130
      Location:382464
      KR; Kringle domain
      pfam00024
      Location:39117
      PAN_1; PAN domain
      pfam00051
      Location:297375
      Kringle; Kringle domain
    12. XM_017006468.2XP_016861957.1  hepatocyte growth factor-like protein isoform X12

    RNA

    1. XR_001740152.2 RNA Sequence

    2. XR_427273.2 RNA Sequence

    3. XR_001740150.2 RNA Sequence

    4. XR_001740149.2 RNA Sequence

    5. XR_001740151.2 RNA Sequence

    6. XR_001740153.2 RNA Sequence

    7. XR_002959536.1 RNA Sequence

    8. XR_940427.2 RNA Sequence

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