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    CD4 CD4 molecule [ Ovis aries (sheep) ]

    Gene ID: 443509, updated on 9-Feb-2019

    Summary

    Gene symbol
    CD4
    Gene description
    CD4 molecule
    See related
    Ensembl:ENSOARG00000006301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs

    Genomic context

    See CD4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Oar_rambouillet_v1.0 (GCF_002742125.1) 3 NC_040254.1 (224399106..224423179, complement)
    102 previous assembly Oar_v4.0 (GCF_000298735.2) 3 NC_019460.2 (207361345..207376307, complement)

    Chromosome 3 - NC_040254.1Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte activating 3 Neighboring gene parathymosin Neighboring gene myeloid leukemia factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sheep Tissue Atlas
    • Description: Sheep total RNA was extracted from embryonic and adult tissues
    • BioProject: PRJEB6169
    • Publication: PMID 24904168
    • Analysis date: Mon Jan 29 09:33:46 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
      Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
      Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    CD4 antigen
    T-cell surface antigen T4/Leu-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129902.1NP_001123374.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_001123374.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ407520
      UniProtKB/TrEMBL
      Q19VJ6
      Related
      ENSOARP00000006750, ENSOART00000006854
      Conserved Domains (5) summary
      smart00410
      Location:28122
      IG_like; Immunoglobulin like
      pfam05790
      Location:314387
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208313
      CD4-extracel; CD4, extracellular
      pfam12104
      Location:423450
      Tcell_CD4_C; T cell CD4 receptor C terminal region
      cl11960
      Location:28120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Ovis aries Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Oar_rambouillet_v1.0 Primary Assembly

    Genomic

    1. NC_040254.1 Reference Oar_rambouillet_v1.0 Primary Assembly

      Range
      224399106..224423179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027965769.1XP_027821570.1  T-cell surface glycoprotein CD4 isoform X1

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