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    AFDN afadin, adherens junction formation factor [ Gallus gallus (chicken) ]

    Gene ID: 421564, updated on 14-Feb-2019

    Summary

    Symbol
    AFDNprovided by CGNC
    Full Name
    afadin, adherens junction formation factorprovided by CGNC
    Primary source
    CGNC:51504
    See related
    Ensembl:ENSGALG00000011329
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    MLLT4
    Orthologs

    Genomic context

    See AFDN in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 3 NC_006090.5 (42206666..42323390, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 3 NC_006090.4 (42233487..42347395, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 3 NC_006090.3 (41392540..41544333, complement)

    Chromosome 3 - NC_006090.5Genomic Context describing neighboring genes Neighboring gene FERM domain containing 1 Neighboring gene uncharacterized LOC107053039 Neighboring gene kinesin family member 25 Neighboring gene uncharacterized LOC112532156 Neighboring gene uncharacterized LOC107053038 Neighboring gene uncharacterized LOC107053037 Neighboring gene unc-93 homolog A (C. elegans)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    General gene information

    Homology

    General protein information

    Preferred Names
    afadin
    Names
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006090.5 Reference GRCg6a Primary Assembly

      Range
      42206666..42323390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015284360.2XP_015139846.1  afadin isoform X17

      Conserved Domains (5) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:9931076
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:597918
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cl00155
      Location:21132
      UBQ; Ubiquitin-like proteins
    2. XM_015284353.2XP_015139839.1  afadin isoform X10

      Conserved Domains (5) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10081091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cl00155
      Location:21132
      UBQ; Ubiquitin-like proteins
    3. XM_015284355.2XP_015139841.1  afadin isoform X12

      Related
      ENSGALP00000053064.2, ENSGALT00000082362.2
      Conserved Domains (5) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10081091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cl00155
      Location:21132
      UBQ; Ubiquitin-like proteins
    4. XM_015284345.2XP_015139831.1  afadin isoform X2

      Conserved Domains (5) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10151098
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cl00155
      Location:21132
      UBQ; Ubiquitin-like proteins
    5. XM_015284352.2XP_015139838.1  afadin isoform X9

      Related
      ENSGALP00000049197.1, ENSGALT00000069813.2
      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:386486
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:9941077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:598919
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    6. XM_015284351.2XP_015139837.1  afadin isoform X8

      Related
      ENSGALP00000055898.2, ENSGALT00000058465.2
      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:386486
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10011084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:598926
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    7. XM_015284356.2XP_015139842.1  afadin isoform X13

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10091092
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613934
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    8. XM_015284348.2XP_015139834.1  afadin isoform X5

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10091092
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613934
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    9. XM_015284347.2XP_015139833.1  afadin isoform X4

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    10. XM_015284350.2XP_015139836.1  afadin isoform X7

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    11. XM_015284358.2XP_015139844.1  afadin isoform X15

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    12. XM_015284349.2XP_015139835.1  afadin isoform X6

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    13. XM_015284346.2XP_015139832.1  afadin isoform X3

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    14. XM_015284357.2XP_015139843.1  afadin isoform X14

      Related
      ENSGALP00000018461.6, ENSGALT00000018484.6
      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    15. XM_015284354.2XP_015139840.1  afadin isoform X11

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    16. XM_015284344.2XP_015139830.1  afadin isoform X1

      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    17. XM_015284359.2XP_015139845.1  afadin isoform X16

      Related
      ENSGALP00000048798.2, ENSGALT00000046353.2
      Conserved Domains (5) summary
      cd01781
      Location:249348
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:21133
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:419501
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd00992
      Location:10161099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15471
      Location:613941
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin

    RNA

    1. XR_001465955.2 RNA Sequence

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