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    pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [ Danio rerio (zebrafish) ]

    Gene ID: 406598, updated on 18-Apr-2019

    Summary

    Official Symbol
    pik3cgprovided by ZNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2532
    See related
    Ensembl:ENSDARG00000017757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:77033; wu:fb15d07
    Orthologs

    Genomic context

    See pik3cg in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (3343173..3355657, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (3329846..3340263, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 4 NC_007115.5 (3214044..3226474, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene protein bicaudal D homolog 1-like Neighboring gene FYVE, RhoGEF and PH domain containing 4b Neighboring gene nicotinamide phosphoribosyltransferase a Neighboring gene synaptophysin-like 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Names
    phosphoinositide-3-kinase, catalytic, gamma polypeptide
    NP_998471.1
    XP_021330656.1
    XP_021330657.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213306.1NP_998471.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_998471.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068983
      UniProtKB/TrEMBL
      Q6NTI2
      Related
      ENSDARP00000002818.6, ENSDART00000009076.8
      Conserved Domains (4) summary
      cd08399
      Location:351522
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:544720
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7241090
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
      pfam00794
      Location:206312
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      3343173..3355657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474981.1XP_021330656.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      Conserved Domains (4) summary
      cd08399
      Location:366537
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:559735
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7391105
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
      pfam00794
      Location:221327
      PI3K_rbd; PI3-kinase family, ras-binding domain
    2. XM_021474982.1XP_021330657.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

      Conserved Domains (4) summary
      cd08399
      Location:366537
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:559735
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      pfam00794
      Location:221327
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl21453
      Location:7391059
      PKc_like; Protein Kinases, catalytic domain
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