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    ADRB2 adrenoceptor beta 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403910, updated on 26-Sep-2018

    Summary

    Gene symbol
    ADRB2
    Gene description
    adrenoceptor beta 2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs

    Genomic context

    See ADRB2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 4 NC_006586.3 (60048502..60050447, complement)

    Chromosome 4 - NC_006586.3Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene uncharacterized LOC111095599 Neighboring gene uncharacterized LOC111095601 Neighboring gene uncharacterized LOC102154501 Neighboring gene uncharacterized LOC612325 Neighboring gene uncharacterized LOC111095720

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006586.3 Chromosome 4 Reference CanFam3.1 Primary Assembly

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
      Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    beta2-adrenergic receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    norepinephrine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    activation of adenylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    desensitization of G protein-coupled receptor signaling pathway by arrestin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of autophagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of lipophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    beta-2 adrenergic receptor
    Names
    adrenergic, beta-2-, receptor, surface
    beta-2 adrenoceptor
    beta-2 adrenoreceptor
    beta2-adrenergic receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003234.1NP_001003234.1  beta-2 adrenergic receptor

      See identical proteins and their annotated locations for NP_001003234.1

      Status: PROVISIONAL

      Source sequence(s)
      X94608
      UniProtKB/Swiss-Prot
      P54833
      Conserved Domains (1) summary
      cd15957
      Location:34336
      7tmA_Beta2_AR; beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006586.3 Reference CanFam3.1 Primary Assembly

      Range
      60048502..60050447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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