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    MAPK14 mitogen-activated protein kinase 14 [ Canis lupus familiaris (dog) ]

    Gene ID: 403856, updated on 2-Oct-2018

    Summary

    Official Symbol
    MAPK14provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 14provided by VGNC
    Primary source
    VGNC:VGNC:42995
    See related
    Ensembl:ENSCAFG00000001378
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs

    Genomic context

    See MAPK14 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 12 NC_006594.3 (5145647..5221558)

    Chromosome 12 - NC_006594.3Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC111098234 Neighboring gene uncharacterized LOC102153575 Neighboring gene mitogen-activated protein kinase 13

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006594.3 Chromosome 12 Reference CanFam3.1 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NFAT protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase p38 binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vascular endothelial growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic membrane adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to muramyl dipeptide IEA
    Inferred from Electronic Annotation
    more info
     
    response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    stress-induced premature senescence IEA
    Inferred from Electronic Annotation
    more info
     
    striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 14
    Names
    MAP kinase 14
    MAP kinase p38 alpha
    MAPK 14
    mitogen-activated protein kinase p38 alpha
    p38 alpha/Mxi2
    p38 mitogen activated protein kinase
    NP_001003206.1
    XP_005627084.1
    XP_013973497.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003206.1NP_001003206.1  mitogen-activated protein kinase 14

      See identical proteins and their annotated locations for NP_001003206.1

      Status: PROVISIONAL

      Source sequence(s)
      AF003597
      UniProtKB/Swiss-Prot
      O02812
      Related
      ENSCAFP00000001968.3, ENSCAFT00000002127.3
      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006594.3 Reference CanFam3.1 Primary Assembly

      Range
      5145647..5221558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014118022.2XP_013973497.1  mitogen-activated protein kinase 14 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:6257
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005627027.3XP_005627084.1  mitogen-activated protein kinase 14 isoform X1

      See identical proteins and their annotated locations for XP_005627084.1

      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
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