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    CASP4 caspase 4, apoptosis-related cysteine peptidase [ Canis lupus familiaris (dog) ]

    Gene ID: 403724, updated on 2-Oct-2018

    Summary

    Gene symbol
    CASP4
    Gene description
    caspase 4, apoptosis-related cysteine peptidase
    See related
    Ensembl:ENSCAFG00000014860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    CASP1
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    See CASP4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 5 NC_006587.3 (27133778..27147954)

    Chromosome 5 - NC_006587.3Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene 60 kDa heat shock protein, mitochondrial pseudogene Neighboring gene uncharacterized LOC106558805 Neighboring gene caspase 12 Neighboring gene 14-3-3 protein theta-like

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006587.3 Chromosome 5 Reference CanFam3.1 Primary Assembly

    Pathways from BioSystems

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    General gene information

    Homology

    Gene Ontology Provided by GO

    Process Evidence Code Pubs
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AIM2 inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    IPAF inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NLRP1 inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NLRP3 inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    caspase-1
    Names
    CASP-1
    ICE
    IL-1 beta-converting enzyme
    IL-1BC
    caspase-1/caspase-4 hybrid
    interleukin-1 beta convertase
    interleukin-1 beta-converting enzyme
    p45
    NP_001003125.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003125.1NP_001003125.1  caspase-1

      See identical proteins and their annotated locations for NP_001003125.1

      Status: PROVISIONAL

      Source sequence(s)
      AF135967
      UniProtKB/Swiss-Prot
      Q9MZV7
      Related
      ENSCAFP00000031566.2, ENSCAFT00000036213.3
      Conserved Domains (2) summary
      smart00115
      Location:153402
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:587
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006587.3 Reference CanFam3.1 Primary Assembly

      Range
      27133778..27147954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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