Format

Send to:

Choose Destination
    • Showing Current items.

    TLR9 toll like receptor 9 [ Canis lupus familiaris (dog) ]

    Gene ID: 403502, updated on 3-Feb-2019

    Summary

    Gene symbol
    TLR9
    Gene description
    toll like receptor 9
    See related
    Ensembl:ENSCAFG00000023201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs

    Genomic context

    See TLR9 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 20 NC_006602.3 (37529322..37547117)

    Chromosome 20 - NC_006602.3Genomic Context describing neighboring genes Neighboring gene microRNA let-7g Neighboring gene WD repeat domain 82 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene twinfilin actin binding protein 2 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene POC1 centriolar protein A Neighboring gene uncharacterized LOC111091319

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006602.3 Chromosome 20 Reference CanFam3.1 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    siRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling pattern recognition receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    unmethylated CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to chloroquine IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of gastrointestinal epithelium IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-beta biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-gamma biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-18 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 9 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of toll-like receptor 9 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to molecule of bacterial origin IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 9 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endolysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    toll-like receptor 9
    Names
    Toll-like receptor 9 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002998.1NP_001002998.1  toll-like receptor 9 precursor

      See identical proteins and their annotated locations for NP_001002998.1

      Status: PROVISIONAL

      Source sequence(s)
      AB104899
      UniProtKB/TrEMBL
      Q865B9
      Related
      ENSCAFP00000030804.2, ENSCAFT00000035532.2
      Conserved Domains (5) summary
      cd00116
      Location:501740
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:754766
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:478499
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:499557
      LRR_8; Leucine rich repeat
      cl23749
      Location:8701013
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006602.3 Reference CanFam3.1 Primary Assembly

      Range
      37529322..37547117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014121724.2XP_013977199.1  toll-like receptor 9 isoform X2

      Conserved Domains (7) summary
      cd11284
      Location:176294
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins
      cd00116
      Location:7941033
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:10471059
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:771792
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:792850
      LRR_8; Leucine rich repeat
      cl23749
      Location:11631306
      TIR_2; TIR domain
    2. XM_014121722.2XP_013977197.1  toll-like receptor 9 isoform X1

      UniProtKB/Swiss-Prot
      Q5I2M8
      Conserved Domains (6) summary
      sd00031
      Location:754766
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:478499
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:703764
      LRR_8; Leucine rich repeat
      cl23749
      Location:8701013
      TIR_2; TIR domain
      cl26018
      Location:28254
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:200721
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    Support Center