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    PARP1 poly (ADP-ribose) polymerase 1 [ Gallus gallus (chicken) ]

    Gene ID: 396199, updated on 14-Feb-2019

    Summary

    Official Symbol
    PARP1provided by CGNC
    Official Full Name
    poly (ADP-ribose) polymerase 1provided by CGNC
    Primary source
    CGNC:7010
    See related
    Ensembl:ENSGALG00000009228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ADPRT; ARTD1; PARP-1
    Orthologs

    Genomic context

    See PARP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 3 NC_006090.5 (17119696..17149617)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 3 NC_006090.4 (17031346..17061269)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 3 NC_006090.3 (16361481..16390721)

    Chromosome 3 - NC_006090.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100859360 Neighboring gene uncharacterized LOC107052966 Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene Mix paired-like homeobox Neighboring gene acyl-CoA binding domain containing 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • BER complex, organism-specific biosystem (from KEGG)
      BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BER complex, conserved biosystem (from KEGG)
      BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ADP-ribosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ADP-ribosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-glutamic acid poly-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein auto-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein poly-ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase NAD(+)
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    DNA ADP-ribosyltransferase PARP1
    NAD(+) ADP-ribosyltransferase 1
    poly (ADP-ribose) polymerase family, member 1
    poly(ADP-ribose) polymerase
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    protein poly-ADP-ribosyltransferase PARP1
    NP_990594.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205263.2NP_990594.2  poly [ADP-ribose] polymerase 1

      Status: VALIDATED

      Source sequence(s)
      AADN05000005
      Related
      ENSGALP00000038037.4, ENSGALT00000038829.4
      Conserved Domains (6) summary
      cd08001
      Location:540642
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:61007
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6591003
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:382458
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1285
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:279330
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006090.5 Reference GRCg6a Primary Assembly

      Range
      17119696..17149617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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