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    chek1 checkpoint kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393162, updated on 14-Feb-2019

    Summary

    Official Symbol
    chek1provided by ZNC
    Official Full Name
    checkpoint kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-896
    See related
    Ensembl:ENSDARG00000104765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:56093; id:ibd2720
    Orthologs

    Genomic context

    See chek1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22558187..22565175)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22521549..22528570)
    103 previous assembly Zv9 (GCF_000002035.4) 21 NC_007132.5 (21673131..21680230)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene myosin VB Neighboring gene cilia and flagella associated protein 53 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene nectin cell adhesion molecule 1a

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • MGC56093

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic G2 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Chk1
    Names
    CHK1 checkpoint homolog
    NP_956487.1
    XP_021324451.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200193.1NP_956487.1  serine/threonine-protein kinase Chk1

      See identical proteins and their annotated locations for NP_956487.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045904
      UniProtKB/TrEMBL
      Q7ZVD7
      Related
      ENSDARP00000133390.1, ENSDART00000167599.2
      Conserved Domains (2) summary
      smart00220
      Location:9216
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:7216
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22558187..22565175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468776.1XP_021324451.1  serine/threonine-protein kinase Chk1 isoform X1

      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1
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