Format

Send to:

Choose Destination
    • Showing Current items.

    Tsen2 tRNA splicing endonuclease subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 381802, updated on 31-Jan-2019

    Summary

    Official Symbol
    Tsen2provided by MGI
    Official Full Name
    tRNA splicing endonuclease subunit 2provided by MGI
    Primary source
    MGI:MGI:2141599
    See related
    Ensembl:ENSMUSG00000042389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU067695
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tsen2 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (115544703..115578340)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (115494722..115528354)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36301 Neighboring gene predicted gene, 36355 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene v-raf-leukemia viral oncogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Clone Names

    • MGC69703

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA splicing, via endonucleolytic cleavage and ligation ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tRNA-splicing endonuclease subunit Sen2
    Names
    tRNA splicing endonuclease 2 homolog
    tRNA-intron endonuclease Sen2
    NP_950198.1
    XP_006506399.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199033.2NP_950198.1  tRNA-splicing endonuclease subunit Sen2

      See identical proteins and their annotated locations for NP_950198.1

      Status: VALIDATED

      Source sequence(s)
      AW542522, BC061473, BY228523
      Consensus CDS
      CCDS20440.1
      UniProtKB/Swiss-Prot
      Q6P7W5
      Related
      ENSMUSP00000038211.7, ENSMUST00000040234.8
      Conserved Domains (3) summary
      COG1676
      Location:292420
      SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
      pfam01974
      Location:334417
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam02778
      Location:278324
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      115544703..115578340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506336.2XP_006506399.1  tRNA-splicing endonuclease subunit Sen2 isoform X1

      Conserved Domains (3) summary
      COG1676
      Location:197325
      SEN2; tRNA splicing endonuclease [Translation, ribosomal structure and biogenesis]
      pfam01974
      Location:239322
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam02778
      Location:183229
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    Support Center