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    POU1F1 POU class 1 homeobox 1 [ Gallus gallus (chicken) ]

    Gene ID: 374215, updated on 3-Apr-2024

    Summary

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    Official Symbol
    POU1F1provided by CGNC
    Official Full Name
    POU class 1 homeobox 1provided by CGNC
    Primary source
    CGNC:11552
    See related
    Ensembl:ENSGALG00010007661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PIT1; GHF-1; PIT-1; Pit-1*
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (93020689..93036563)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (93058808..93074681)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene cell surface glycoprotein CD200 receptor 1-A-like Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene uncharacterized LOC121109439 Neighboring gene charged multivesicular body protein 2B Neighboring gene vestigial like family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms of Pit-1 gene and its association with growth traits in chicken. Bhattacharya TK, et al. Poult Sci, 2012 May. PMID 22499861
    2. The PIT1 gene polymorphisms were associated with chicken growth traits. Nie Q, et al. BMC Genet, 2008 Feb 27. PMID 18304318, Free PMC Article
    3. Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary. Van As P, et al. Acta Vet Hung, 2004. PMID 15595273
    4. A new single nucleotide polymorphism in the chicken pituitary-specific transcription factor (POU1F1) gene associated with growth rate. Jiang R, et al. Anim Genet, 2004 Aug. PMID 15265078
    5. Immunocytochemical identification of Pit-1 containing cells in the anterior pituitary of hens. Chowdhury VS, et al. J Reprod Dev, 2003 Oct. PMID 14967913

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of differential abilities of chicken Pit1 isoforms to regulate the GH promoter
      Title: Differential abilities of chicken Pit1 isoforms to regulate the GH promoter: evidence for synergistic activation.
    2. The Pit-1 gene is polymorphic and has a significant effect on growth traits in chickens.
      Title: Polymorphisms of Pit-1 gene and its association with growth traits in chicken.
    3. Data preliminarily deduced that MC4R and POU1F1 gene were probably the major gene on growth performance or a QTL linked gene which associated with growth performance in chicken.
      Title: [Genetic effects of MC4R and POU1F1 gene on the growth performance in Jinghai yellow chicken].
    4. Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits
      Title: The PIT1 gene polymorphisms were associated with chicken growth traits.
    5. Pit-1 has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH.
      Title: Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary.
    6. Pit-1 protein induction occurs in 6 types of glandular cells, suggesting that Pit-1 may regulate hormone synthesis in each glandular cell in the anterior pituitary.
      Title: Immunocytochemical identification of Pit-1 containing cells in the anterior pituitary of hens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pituitary-specific positive transcription factor 1
    Names
    POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
    Pit-1/GHF-1
    growth hormone factor 1
    pituitary specific transcription factor
    pituitary specific transcription factor-1
    pituitary-specific positive transcription factor 1 variant alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396102.1 → NP_001383031.1  pituitary-specific positive transcription factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000019
      UniProtKB/Swiss-Prot
      Q9YGL7, Q9YGL8
      UniProtKB/TrEMBL
      A0A1D5NY46
      Related
      ENSGALP00010010024.1, ENSGALT00010018244.1
      Conserved Domains (2) summary
      smart00352
      Location:195 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      smart00389
      Location:285 → 341
      HOX; Homeodomain

    2. NM_001396103.1 → NP_001383032.1  pituitary-specific positive transcription factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000019
      UniProtKB/Swiss-Prot
      Q9YGL7, Q9YGL8
      Conserved Domains (2) summary
      smart00352
      Location:167 → 241
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:260 → 314
      Homeobox; Homeobox domain

    3. NM_204319.2 → NP_989650.1  pituitary-specific positive transcription factor 1 isoform 3

      See identical proteins and their annotated locations for NP_989650.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000019
      UniProtKB/TrEMBL
      F1NRJ0, H6U644, O57599
      Conserved Domains (2) summary
      smart00352
      Location:159 → 233
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:252 → 305
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      93020689..93036563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015295651.3 → XP_015151137.1  pituitary-specific positive transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9YGL7, Q9YGL8
      Conserved Domains (2) summary
      smart00352
      Location:202 → 276
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:295 → 348
      Homeobox; Homeobox domain

    2. XM_015295656.3 → XP_015151142.1  pituitary-specific positive transcription factor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9YGL7, Q9YGL8
      Conserved Domains (2) summary
      smart00352
      Location:174 → 248
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:267 → 320
      Homeobox; Homeobox domain

    3. XM_046943757.1 → XP_046799713.1  pituitary-specific positive transcription factor 1 isoform X3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      93058808..93074681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906421.1 → XP_046762377.1  pituitary-specific positive transcription factor 1 isoform X1

    2. XM_046906422.1 → XP_046762378.1  pituitary-specific positive transcription factor 1 isoform X2

    3. XM_046906423.1 → XP_046762379.1  pituitary-specific positive transcription factor 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YGL7.1 GenPept UniProtKB/Swiss-Prot:Q9YGL7

    Gene LinkOut

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