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    ITGB4 integrin subunit beta 4 [ Homo sapiens (human) ]

    Gene ID: 3691, updated on 23-Apr-2019

    Summary

    Official Symbol
    ITGB4provided by HGNC
    Official Full Name
    integrin subunit beta 4provided by HGNC
    Primary source
    HGNC:HGNC:6158
    See related
    Ensembl:ENSG00000132470 MIM:147557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD104; GP150
    Summary
    Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in stomach (RPKM 27.7), skin (RPKM 23.3) and 19 other tissues See more
    Orthologs

    Genomic context

    See ITGB4 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (75721328..75757819)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73717516..73753899)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 5 Neighboring gene uncharacterized LOC107985013 Neighboring gene SAP30 binding protein Neighboring gene ITGB4 intron CAGE-defined low expression enhancer Neighboring gene galactokinase 1 Neighboring gene H3 histone family member 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat A monoclonal antibody to beta 4 integrin inhibited cellular attachment of HIV-1 Tat by over 90%, suggesting an interaction between Tat and the beta 4 integrin subunit in cell attachment to Tat PubMed
    retropepsin gag-pol Beta4 integrin and alpha3 integrin are cleaved by the HIV-1 protease in human embryonic fibroblasts PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Alpha 6 Beta 4 signaling pathway, organism-specific biosystem (from WikiPathways)
      Alpha 6 Beta 4 signaling pathway, organism-specific biosystemThe integrin alpha6beta4 was discovered in the late 1980s by two different groups and was called either alphaEbeta4 or Ic-Ic binding protein (Ic-IcBP) (1,2). The alpha6beta4 integrin is a component o...
    • Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystem (from WikiPathways)
      Arrhythmogenic Right Ventricular Cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Assembly of collagen fibrils and other multimeric structures, organism-specific biosystem (from REACTOME)
      Assembly of collagen fibrils and other multimeric structures, organism-specific biosystemCollagen trimers in triple-helical form, referred to as procollagen or collagen molecules, are exported from the ER and trafficked through the Golgi network before secretion into the extracellular sp...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Collagen formation, organism-specific biosystem (from REACTOME)
      Collagen formation, organism-specific biosystemCollagen is a family of at least 29 structural proteins derived from over 40 human genes (Myllyharju & Kivirikko 2004). It is the main component of connective tissue, and the most abundant protein in...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Laminin interactions, organism-specific biosystem (from REACTOME)
      Laminin interactions, organism-specific biosystemLaminins are a large family of conserved, multidomain trimeric basement membrane proteins. There are many theoretical trimer combinations but only 18 have been described (Domogatskaya et al. 2012, Mi...
    • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
      Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystem (from WikiPathways)
      Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystemThis pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling....
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Syndecan interactions, organism-specific biosystem (from REACTOME)
      Syndecan interactions, organism-specific biosystemSyndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. ...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • Type I hemidesmosome assembly, organism-specific biosystem (from REACTOME)
      Type I hemidesmosome assembly, organism-specific biosystemHemidesmosomes (HDs) are specialized multiprotein junctional complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix and play a critical role in the maintenan...
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to insulin-like growth factor I binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to neuregulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    amelogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    hemidesmosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemidesmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemidesmosome assembly TAS
    Traceable Author Statement
    more info
     
    mesodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    nail development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-4
    Names
    CD104 antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007372.1 RefSeqGene

      Range
      4893..41384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000213.5NP_000204.3  integrin beta-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000204.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087749, AI318403, CA391583, X51841, X52186, X53587
      Consensus CDS
      CCDS11727.1
      UniProtKB/Swiss-Prot
      P16144
      UniProtKB/TrEMBL
      A0A024R8T0
      Related
      ENSP00000200181.3, ENST00000200181.8
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15291611
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
    2. NM_001005619.1NP_001005619.1  integrin beta-4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001005619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in one place but has an additional in-frame exon in another place, as compared to variant 1. The encoded isoform 2 thus differs in two regions, as compared to isoform 1.
      Source sequence(s)
      AI318403, X51841, X52186, X53587
      Consensus CDS
      CCDS32736.1
      UniProtKB/Swiss-Prot
      P16144
      Related
      ENSP00000400217.2, ENST00000449880.6
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15121594
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
    3. NM_001005731.2NP_001005731.1  integrin beta-4 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001005731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC087749, AI318403, CA391583, X51841, X52186, X53587
      Consensus CDS
      CCDS58599.1
      UniProtKB/Swiss-Prot
      P16144
      UniProtKB/TrEMBL
      A0A024R8K7
      Related
      ENSP00000405536.3, ENST00000450894.7
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14591541
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
    4. NM_001321123.1NP_001308052.1  integrin beta-4 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC087749, BC143742, CA391583, X51841, X52186
      Consensus CDS
      CCDS58599.1
      UniProtKB/Swiss-Prot
      P16144
      UniProtKB/TrEMBL
      A0A024R8K7, B7ZLD8
      Related
      ENSP00000463651.1, ENST00000579662.5
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14591541
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      75721328..75757819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257311.4XP_005257368.1  integrin beta-4 isoform X2

      See identical proteins and their annotated locations for XP_005257368.1

      UniProtKB/TrEMBL
      A0A024R8N2
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15821664
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
    2. XM_005257309.2XP_005257366.1  integrin beta-4 isoform X2

      See identical proteins and their annotated locations for XP_005257366.1

      UniProtKB/TrEMBL
      A0A024R8N2
      Conserved Domains (6) summary
      cd00063
      Location:12201313
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15821664
      fn3; Fibronectin type III domain
      pfam00362
      Location:37453
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:9901084
      Calx-beta; Calx-beta domain
      pfam07965
      Location:626709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:543573
      EGF_2; EGF-like domain
    3. XM_006721866.3XP_006721929.1  integrin beta-4 isoform X1

      Conserved Domains (6) summary
      cd00063
      Location:12551348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16171699
      fn3; Fibronectin type III domain
      pfam00362
      Location:72488
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:10251119
      Calx-beta; Calx-beta domain
      pfam07965
      Location:661744
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:578608
      EGF_2; EGF-like domain
    4. XM_011524751.2XP_011523053.1  integrin beta-4 isoform X5

      Conserved Domains (6) summary
      cd00063
      Location:12551348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16271712
      fn3; Fibronectin type III domain
      pfam00362
      Location:72488
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:10251119
      Calx-beta; Calx-beta domain
      pfam07965
      Location:661744
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:578608
      EGF_2; EGF-like domain
    5. XM_006721867.3XP_006721930.1  integrin beta-4 isoform X3

      Conserved Domains (6) summary
      cd00063
      Location:12551348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15641646
      fn3; Fibronectin type III domain
      pfam00362
      Location:72488
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:10251119
      Calx-beta; Calx-beta domain
      pfam07965
      Location:661744
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:578608
      EGF_2; EGF-like domain
    6. XM_006721868.3XP_006721931.1  integrin beta-4 isoform X4

      Conserved Domains (6) summary
      cd00063
      Location:12551348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15471629
      fn3; Fibronectin type III domain
      pfam00362
      Location:72488
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:10251119
      Calx-beta; Calx-beta domain
      pfam07965
      Location:661744
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:578608
      EGF_2; EGF-like domain
    7. XM_006721870.3XP_006721933.1  integrin beta-4 isoform X6

      Conserved Domains (6) summary
      cd00063
      Location:12551348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14941576
      fn3; Fibronectin type III domain
      pfam00362
      Location:72488
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:10251119
      Calx-beta; Calx-beta domain
      pfam07965
      Location:661744
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:578608
      EGF_2; EGF-like domain
    8. XM_011524752.2XP_011523054.1  integrin beta-4 isoform X7

      Conserved Domains (3) summary
      cd00063
      Location:535628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:897979
      fn3; Fibronectin type III domain
      pfam03160
      Location:305399
      Calx-beta; Calx-beta domain
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