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    Plxna1 plexin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362398, updated on 18-Apr-2019

    Summary

    Official Symbol
    Plxna1provided by RGD
    Official Full Name
    plexin A1provided by RGD
    Primary source
    RGD:1560871
    See related
    Ensembl:ENSRNOG00000017003
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560871
    Expression
    Biased expression in Lung (RPKM 197.4), Adrenal (RPKM 91.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Plxna1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (121217658..121262697, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (186455209..186500246, complement)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555094 Neighboring gene proline rich 20E Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene thioredoxin reductase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    semaphorin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    dichotomous subdivision of terminal units involved in salivary gland branching IEA
    Inferred from Electronic Annotation
    more info
     
    dichotomous subdivision of terminal units involved in salivary gland branching ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection guidance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    semaphorin-plexin signaling pathway involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      121217658..121262697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002729398.5XP_002729444.2  plexin-A1 isoform X1

      See identical proteins and their annotated locations for XP_002729444.2

      UniProtKB/TrEMBL
      D3Z981
      Related
      ENSRNOP00000022951.6, ENSRNOT00000022951.6
      Conserved Domains (7) summary
      cd11271
      Location:54529
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cd01179
      Location:9771062
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:880976
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10641164
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:530572
      PSI; Plexin repeat
      pfam01833
      Location:11661250
      TIG; IPT/TIG domain
      pfam08337
      Location:13341882
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      110688907..110729767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001072622.6XP_001072622.3  plexin-A1 isoform X2

      Conserved Domains (7) summary
      cd11271
      Location:86561
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cd01179
      Location:10091094
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:9121008
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10961196
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:562604
      PSI; Plexin repeat
      pfam01833
      Location:11981282
      TIG; IPT/TIG domain
      pfam08337
      Location:13661914
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
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