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    Tead1 TEA domain transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361630, updated on 18-Nov-2018

    Summary

    Official Symbol
    Tead1provided by RGD
    Official Full Name
    TEA domain transcription factor 1provided by RGD
    Primary source
    RGD:1549742
    See related
    Ensembl:ENSRNOG00000015488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TEF-1
    Expression
    Biased expression in Heart (RPKM 148.6), Muscle (RPKM 145.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Tead1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (177495500..177714795)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (184473090..184690968)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349616 Neighboring gene parvin, alpha Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene Ras association domain family member 10 Neighboring gene uncharacterized LOC102547978

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulator recruiting activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    lateral mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    notochord development ISO
    Inferred from Sequence Orthology
    more info
     
    paraxial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    transition between fast and slow fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    TEAD-1-YAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-1
    Names
    TEA domain family member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198589.1NP_001185518.1  transcriptional enhancer factor TEF-1

      See identical proteins and their annotated locations for NP_001185518.1

      Status: VALIDATED

      Source sequence(s)
      AABR07005039, AABR07005040, AY529195
      UniProtKB/TrEMBL
      F1M7P3, Q6QQU2
      Related
      ENSRNOP00000021020.3, ENSRNOT00000021020.4
      Conserved Domains (1) summary
      smart00426
      Location:1582
      TEA; TEA domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      177495500..177714795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230052.2XP_006230114.1  transcriptional enhancer factor TEF-1 isoform X1

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    2. XM_006230053.2XP_006230115.1  transcriptional enhancer factor TEF-1 isoform X2

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    3. XM_006230055.2XP_006230117.1  transcriptional enhancer factor TEF-1 isoform X4

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    4. XM_006230057.2XP_006230119.1  transcriptional enhancer factor TEF-1 isoform X6

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    5. XM_006230054.2XP_006230116.1  transcriptional enhancer factor TEF-1 isoform X3

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    6. XM_006230056.2XP_006230118.1  transcriptional enhancer factor TEF-1 isoform X5

      Conserved Domains (1) summary
      smart00426
      Location:210277
      TEA; TEA domain
    7. XM_006230058.2XP_006230120.1  transcriptional enhancer factor TEF-1 isoform X7

      Conserved Domains (1) summary
      smart00426
      Location:210269
      TEA; TEA domain
    8. XM_006230059.2XP_006230121.1  transcriptional enhancer factor TEF-1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K2N3
      Related
      ENSRNOP00000072311.1, ENSRNOT00000090042.1
      Conserved Domains (1) summary
      smart00426
      Location:1582
      TEA; TEA domain
    9. XM_008759768.1XP_008757990.1  transcriptional enhancer factor TEF-1 isoform X9

      Conserved Domains (1) summary
      smart00426
      Location:53120
      TEA; TEA domain
    10. XM_008759767.2XP_008757989.1  transcriptional enhancer factor TEF-1 isoform X8

      Conserved Domains (1) summary
      smart00426
      Location:56123
      TEA; TEA domain

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      164664658..164874391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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