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    HSP90AA2P heat shock protein 90 alpha family class A member 2, pseudogene [ Homo sapiens (human) ]

    Gene ID: 3324, updated on 3-Mar-2019

    Summary

    Official Symbol
    HSP90AA2Pprovided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 2, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:5256
    See related
    MIM:140575
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPCA; HSPCAL3; HSP90AA2; HSP90ALPHA
    Summary
    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]

    Genomic context

    See HSP90AA2P in Genome Data Viewer
    Location:
    11p14.1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (27888171..27891092, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27909718..27912639, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BDNF antisense RNA Neighboring gene brain derived neurotrophic factor Neighboring gene chromobox 3 pseudogene 1 Neighboring gene kinesin family member 18A Neighboring gene microRNA 610 Neighboring gene methyltransferase like 15 Neighboring gene ATP synthase membrane subunit g pseudogene 8

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • heat shock 90kD protein, alpha-like 3
    • heat shock 90kDa protein 1, alpha-like 3
    • heat shock protein 86
    • heat shock protein 90kDa alpha (cytosolic), class A member 1 pseudogene
    • heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
    • heat shock protein 90kDa alpha family class A member 2, pseudogene

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    disordered domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    nitric-oxide synthase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005856.3 

      Range
      101..3022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      27888171..27891092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040141.1: Suppressed sequence

      Description
      NM_001040141.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
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