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    Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316395, updated on 2-Oct-2018

    Summary

    Official Symbol
    Hecw2provided by RGD
    Official Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1593244
    See related
    Ensembl:ENSRNOG00000013257
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Brain (RPKM 86.0), Lung (RPKM 72.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Hecw2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60451476..60843160, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (60137069..60526937, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 10 Neighboring gene dynein, axonemal, heavy chain 7 Neighboring gene serine/threonine kinase 17b Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene coiled-coil domain containing 150 Neighboring gene general transcription factor IIIC subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HECW2
    NP_001101688.1
    XP_006244974.1
    XP_017451936.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108218.1NP_001101688.1  E3 ubiquitin-protein ligase HECW2

      See identical proteins and their annotated locations for NP_001101688.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      D4ADD3
      Related
      ENSRNOP00000017761.5, ENSRNOT00000017761.5
      Conserved Domains (7) summary
      pfam06390
      Location:464632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00119
      Location:12461575
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:12221576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815844
      WW; WW domain
      pfam14797
      Location:570688
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam16562
      Location:45164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      60451476..60843160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596447.1XP_017451936.1  E3 ubiquitin-protein ligase HECW2 isoform X1

      UniProtKB/TrEMBL
      D4ADD3
      Conserved Domains (7) summary
      pfam06390
      Location:464632
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:185321
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00119
      Location:12461575
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:12221576
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:815844
      WW; WW domain
      pfam14797
      Location:570688
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam16562
      Location:45164
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    2. XM_006244912.3XP_006244974.1  E3 ubiquitin-protein ligase HECW2 isoform X2

      Conserved Domains (7) summary
      pfam06390
      Location:333501
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd08691
      Location:54190
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00119
      Location:11151444
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:10911445
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:684713
      WW; WW domain
      pfam14797
      Location:439557
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam16562
      Location:133
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      52860020..53074467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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