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    Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315139, updated on 18-Apr-2019

    Summary

    Official Symbol
    Tab1provided by RGD
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by RGD
    Primary source
    RGD:1306216
    See related
    Ensembl:ENSRNOG00000017285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Map3k7ip1
    Expression
    Biased expression in Thymus (RPKM 120.7), Kidney (RPKM 110.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Tab1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121350953..121382100)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (121340948..121371923)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene synaptogyrin 1 Neighboring gene ubiquitin-conjugating enzyme E2 S-like Neighboring gene mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase Neighboring gene mitochondrial elongation factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    magnesium-dependent protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase p38 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase p38 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of MAPKKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    aorta development IEA
    Inferred from Electronic Annotation
    more info
     
    aorta development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac septum development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Names
    Tak1-binding protein 1
    mitogen-activated protein kinase kinase kinase 7 interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109976.2NP_001103446.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

      See identical proteins and their annotated locations for NP_001103446.1

      Status: VALIDATED

      Source sequence(s)
      BP466072, BP483385, CB605878, CB706441, CB802111, CO567997, DN948807, DY311072, EV771639
      UniProtKB/TrEMBL
      A0A0U1RRU5
      Related
      ENSRNOP00000075816.1, ENSRNOT00000092614.1
      Conserved Domains (1) summary
      pfam00481
      Location:69334
      PP2C; Protein phosphatase 2C

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      121350953..121382100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      108004014..108035121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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