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    Ptges2 prostaglandin E synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311865, updated on 19-Apr-2019

    Summary

    Official Symbol
    Ptges2provided by RGD
    Official Full Name
    prostaglandin E synthase 2provided by RGD
    Primary source
    RGD:1310836
    See related
    Ensembl:ENSRNOG00000014050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 172.7), Muscle (RPKM 165.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ptges2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11424195..11431379)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (16773065..16780249)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene similar to Hypothetical UPF0184 protein C9orf16 homolog Neighboring gene lipocalin 2 Neighboring gene solute carrier family 25 member 25 Neighboring gene nuclear apoptosis inducing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-E synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-E synthase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    secretion IEA
    Inferred from Electronic Annotation
    more info
     
    secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    prostaglandin E synthase 2
    NP_001101302.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107832.1NP_001101302.1  prostaglandin E synthase 2

      See identical proteins and their annotated locations for NP_001101302.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      D4AE56
      Related
      ENSRNOP00000019184.4, ENSRNOT00000019184.6
      Conserved Domains (3) summary
      cd03197
      Location:223371
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
      COG0625
      Location:101368
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03040
      Location:100176
      GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      11424195..11431379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      10433385..10440575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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