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    Map3k11 mitogen-activated protein kinase kinase kinase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309168, updated on 14-Oct-2018

    Summary

    Symbol
    Map3k11provided by RGD
    Full Name
    mitogen-activated protein kinase kinase kinase 11provided by RGD
    Primary source
    RGD:1359261
    See related
    Ensembl:ENSRNOG00000020773
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mlk3; RHOE; Mlk-3
    Expression
    Biased expression in Lung (RPKM 154.6), Kidney (RPKM 123.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Map3k11 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221043119..221056420)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (227978441..227991742)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene signal-induced proliferation-associated 1 Neighboring gene pecanex 3 Neighboring gene uncharacterized LOC102546344 Neighboring gene potassium two pore domain channel subfamily K member 7 Neighboring gene EH domain binding protein 1-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    JUN kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rac GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JNKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 11
    Names
    mixed lineage kinase 3
    NP_001013168.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013150.1NP_001013168.1  mitogen-activated protein kinase kinase kinase 11

      See identical proteins and their annotated locations for NP_001013168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081952
      UniProtKB/Swiss-Prot
      Q66HA1
      Related
      ENSRNOP00000028185.4, ENSRNOT00000028185.5
      Conserved Domains (3) summary
      cd12059
      Location:46103
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      smart00221
      Location:118377
      STYKc; Protein kinase; unclassified specificity
      cd14147
      Location:114380
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      221043119..221056420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      200511102..200524400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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