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    Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308267, updated on 19-Apr-2019

    Summary

    Official Symbol
    Tab2provided by RGD
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by RGD
    Primary source
    RGD:1309527
    See related
    Ensembl:ENSRNOG00000016054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Map3k7ip2
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Muscle (RPKM 106.9), Thymus (RPKM 102.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Tab2 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1999574..2017574, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (3695737..3770496, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 4 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene uncharacterized LOC108349482 Neighboring gene similar to ets variant gene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    K63-linked polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TGF-beta-activated kinase 1-binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012062.1NP_001012062.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      See identical proteins and their annotated locations for NP_001012062.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085788
      UniProtKB/Swiss-Prot
      Q5U303
      Related
      ENSRNOP00000058709.2, ENSRNOT00000061999.5
      Conserved Domains (2) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam15035
      Location:534612
      Rootletin; Ciliary rootlet component, centrosome cohesion

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      1999574..2017574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      924327..972936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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