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    Bmi1 BMI1 proto-oncogene, polycomb ring finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307151, updated on 18-Apr-2019

    Summary

    Official Symbol
    Bmi1provided by RGD
    Official Full Name
    BMI1 proto-oncogene, polycomb ring fingerprovided by RGD
    Primary source
    RGD:1307403
    See related
    Ensembl:ENSRNOG00000016585
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcgf4
    Expression
    Biased expression in Lung (RPKM 131.8), Heart (RPKM 108.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Bmi1 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (85360439..85370283)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (87087687..87091418)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene transfer RNA asparagine (anticodon GUU) Neighboring gene basic proline-rich protein-like Neighboring gene COMM domain containing 3 Neighboring gene uncharacterized LOC108348597 Neighboring gene sperm associated antigen 6-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    brain development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone H2A-K119 monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H2A-K119 monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of immature T cell proliferation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of adaxial/abaxial pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of adaxial/abaxial pattern formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rostrocaudal neural tube patterning IEA
    Inferred from Electronic Annotation
    more info
     
    rostrocaudal neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    somatic stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb complex protein BMI-1
    Names
    B lymphoma Mo-MLV insertion region 1
    Bmi1 polycomb ring finger oncogene
    polycomb group ring finger 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107368.2NP_001100838.1  polycomb complex protein BMI-1

      See identical proteins and their annotated locations for NP_001100838.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168209
      UniProtKB/TrEMBL
      B4F7B6
      Related
      ENSRNOP00000059998.1, ENSRNOT00000064257.2
      Conserved Domains (2) summary
      pfam00097
      Location:1856
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:153224
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      85360439..85370283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600573.1XP_017456062.1  polycomb complex protein BMI-1 isoform X1

      UniProtKB/TrEMBL
      B4F7B6
      Conserved Domains (2) summary
      pfam00097
      Location:1856
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:153224
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      80616376..80620118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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