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    Adcy1 adenylate cyclase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305509, updated on 4-Dec-2018

    Summary

    Official Symbol
    Adcy1provided by RGD
    Official Full Name
    adenylate cyclase 1provided by RGD
    Primary source
    RGD:1309318
    See related
    Ensembl:ENSRNOG00000059479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ac1
    Expression
    Biased expression in Brain (RPKM 605.5), Kidney (RPKM 65.7) and 1 other tissue See more
    Orthologs

    Genomic context

    See Adcy1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (87311970..87429880)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (80947153..81055801)

    Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352857 Neighboring gene uncharacterized LOC108352792 Neighboring gene uncharacterized LOC102553858 Neighboring gene insulin-like growth factor binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium- and calmodulin-responsive adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of CREB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenylate cyclase type 1
    Names
    adenylate cyclase 1 (brain)
    NP_001100709.1
    XP_008768542.2
    XP_008768543.2
    XP_017454723.1
    XP_017454724.1
    XP_017454725.1
    XP_017454726.1
    XP_017454727.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107239.1NP_001100709.1  adenylate cyclase type 1

      See identical proteins and their annotated locations for NP_001100709.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474055
      UniProtKB/TrEMBL
      D4A3N4
      Related
      ENSRNOP00000070999.1, ENSRNOT00000088032.1
      Conserved Domains (3) summary
      smart00044
      Location:105300
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:706903
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:6139
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

      Range
      87311970..87429880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599234.1XP_017454723.1  adenylate cyclase type 1 isoform X1

    2. XM_017599235.1XP_017454724.1  adenylate cyclase type 1 isoform X3

    3. XM_017599238.1XP_017454727.1  adenylate cyclase type 1 isoform X6

    4. XM_008770320.2XP_008768542.2  adenylate cyclase type 1 isoform X2

    5. XM_008770321.2XP_008768543.2  adenylate cyclase type 1 isoform X4

      UniProtKB/TrEMBL
      D4A3N4
      Conserved Domains (3) summary
      smart00044
      Location:105300
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:706903
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:6139
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    6. XM_017599237.1XP_017454726.1  adenylate cyclase type 1 isoform X1

    7. XM_017599236.1XP_017454725.1  adenylate cyclase type 1 isoform X5

    Alternate Rn_Celera

    Genomic

    1. AC_000082.1 Alternate Rn_Celera

      Range
      80985818..81095021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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