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    Muc4 mucin 4, cell surface associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303887, updated on 18-Apr-2019

    Summary

    Official Symbol
    Muc4provided by RGD
    Official Full Name
    mucin 4, cell surface associatedprovided by RGD
    Primary source
    RGD:621331
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psmc; ASGP-1
    Summary
    a glycoprotein involved in conferring mucous visoelasticity; may have growth factor-modulating activity and have a role in tumor progression [RGD, Feb 2006]
    Expression
    Biased expression in Uterus (RPKM 117.2), Adrenal (RPKM 11.1) and 1 other tissue See more
    Orthologs

    Genomic context

    See Muc4 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71242973..71285217, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (74327777..74369829, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910650 Neighboring gene uncharacterized LOC103693588 Neighboring gene mucin 20, cell surface associated Neighboring gene tyrosine kinase, non-receptor, 2 Neighboring gene transferrin receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ErbB-2 class receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    extracellular matrix constituent, lubricant activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    digestive tract development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epithelial structure maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    estrous cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mammary gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of T cell mediated cytotoxicity directed against tumor cell target IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-embryonic camera-type eye development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mucin-4
    Names
    ASGP
    MUC-4
    ascites sialoglycoprotein
    pancreatic adenocarcinoma mucin
    pre-sialomucin complex
    sialomucin ascites sialoglycoprotein-1
    sialomucin complex
    testis mucin

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      71242973..71285217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768776.2XP_008766998.1  mucin-4 isoform X2

      Conserved Domains (3) summary
      smart00539
      Location:8711027
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam00094
      Location:11541324
      VWD; von Willebrand factor type D domain
      cl02758
      Location:10291139
      AMOP; AMOP domain
    2. XM_017598174.1XP_017453663.1  mucin-4 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      67453205..67496554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006221167.3XP_006221229.1  mucin-4 isoform X3

      Conserved Domains (4) summary
      smart00216
      Location:19992179
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:17271883
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam00008
      Location:26562680
      EGF; EGF-like domain
      cl02758
      Location:18851995
      AMOP; AMOP domain
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