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    Kat2a lysine acetyltransferase 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303539, updated on 19-Apr-2019

    Summary

    Official Symbol
    Kat2aprovided by RGD
    Official Full Name
    lysine acetyltransferase 2Aprovided by RGD
    Primary source
    RGD:1307242
    See related
    Ensembl:ENSRNOG00000018364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcn5; Gcn5l2
    Expression
    Biased expression in Brain (RPKM 66.2), Adrenal (RPKM 57.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Kat2a in Genome Data Viewer
    Location:
    10q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88611586..88619558, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (88405799..88413761, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385C Neighboring gene DEXH-box helicase 58 Neighboring gene heat shock protein family B (small) member 9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene potassium voltage-gated channel subfamily H member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    H3 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase activity (H4-K12 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase activity (H4-K12 specific) ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    alpha-tubulin acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone H3-K14 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone H4-K12 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone succinylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone succinylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    metencephalon development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of regulatory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    telencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IEA
    Inferred from Electronic Annotation
    more info
     
    Ada2/Gcn5/Ada3 transcription activator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    STAGA complex IEA
    Inferred from Electronic Annotation
    more info
     
    STAGA complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor TFTC complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase KAT2A
    Names
    GCN5 general control of amino acid synthesis-like 2
    K(lysine) acetyltransferase 2A
    general control of amino acid synthesis 5-like 2
    NP_001100520.1
    XP_006247379.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107050.1NP_001100520.1  histone acetyltransferase KAT2A

      See identical proteins and their annotated locations for NP_001100520.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      D4ACX5
      Related
      ENSRNOP00000052125.3, ENSRNOT00000055250.3
      Conserved Domains (4) summary
      cd05509
      Location:727826
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:487827
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:550622
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:81330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      88611586..88619558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247317.3XP_006247379.1  histone acetyltransferase KAT2A isoform X1

      Conserved Domains (4) summary
      cd05509
      Location:728827
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:488828
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:551623
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:81330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      84347901..84355851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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