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    Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299802, updated on 18-Apr-2019

    Summary

    Official Symbol
    Lgr5provided by RGD
    Official Full Name
    leucine rich repeat containing G protein coupled receptor 5provided by RGD
    Primary source
    RGD:1307733
    See related
    Ensembl:ENSRNOG00000004221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr49
    Expression
    Biased expression in Uterus (RPKM 35.4), Brain (RPKM 16.7) and 6 other tissues See more
    Orthologs

    Genomic context

    See Lgr5 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58447097..58587787, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (58458486..58596253, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene zinc finger, C3H1-type containing Neighboring gene hypothetical protein LOC100362230 Neighboring gene similar to mitochondrial ribosomal protein L50 Neighboring gene uncharacterized LOC102551386 Neighboring gene tetraspanin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein-hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    activation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    epithelial cell proliferation involved in renal tubule morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in renal tubule morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inner ear development IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    oocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing G-protein coupled receptor 5
    Names
    G protein-coupled receptor 49

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106784.1NP_001100254.1  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

      See identical proteins and their annotated locations for NP_001100254.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/Swiss-Prot
      D4AC13
      Related
      ENSRNOP00000005814.3, ENSRNOT00000005814.4
      Conserved Domains (6) summary
      smart00013
      Location:3370
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:88372
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:445467
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:6891
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:575820
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      58447097..58587787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594740.1XP_017450229.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      47880362..48010031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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