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    Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298947, updated on 18-Apr-2019

    Summary

    Official Symbol
    Pik3cgprovided by RGD
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaprovided by RGD
    Primary source
    RGD:1306468
    See related
    Ensembl:ENSRNOG00000009385
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pi3k
    Expression
    Biased expression in Thymus (RPKM 145.7), Spleen (RPKM 108.5) and 8 other tissues See more
    Orthologs

    Genomic context

    See Pik3cg in Genome Data Viewer
    Location:
    6q16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51465696..51501234, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (61106730..61142184, complement)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L18a-like Neighboring gene HMG-box transcription factor 1 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene hypothetical LOC100361355 Neighboring gene coiled-coil domain containing 71-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    secretory granule localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex, class IB IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex, class IB ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Names
    phosphoinositide-3-kinase, catalytic, gamma polypeptide
    XP_003750188.1
    XP_006240065.1
    XP_006240066.1
    XP_006240067.1
    XP_017458652.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      51465696..51501234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240005.3XP_006240067.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_006240067.1

      UniProtKB/TrEMBL
      D3ZFJ0
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    2. XM_006240003.3XP_006240065.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_006240065.1

      UniProtKB/TrEMBL
      D3ZFJ0
      Related
      ENSRNOP00000012487.3, ENSRNOT00000012487.5
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    3. XM_006240004.3XP_006240066.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_006240066.1

      UniProtKB/TrEMBL
      D3ZFJ0
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
    4. XM_003750140.4XP_003750188.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_003750188.1

      UniProtKB/TrEMBL
      D3ZFJ0
      Conserved Domains (4) summary
      cd08399
      Location:350527
      C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:203312
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:549725
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd00894
      Location:7291095
      PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      47971127..48004061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017603163.1XP_017458652.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106723.1: Suppressed sequence

      Description
      NM_001106723.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PIK3CG (GeneID:5294).
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