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    Psma1 proteasome subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29668, updated on 18-Apr-2019

    Summary

    Official Symbol
    Psma1provided by RGD
    Official Full Name
    proteasome subunit alpha 1provided by RGD
    Primary source
    RGD:61841
    See related
    Ensembl:ENSRNOG00000011745
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    component of the proteasome multicatalytic proteinase complex [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 708.2), Thymus (RPKM 579.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See Psma1 in Genome Data Viewer
    Location:
    1q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (183733567..183744586, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (190708745..190719764, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene similar to ribosomal protein S18 Neighboring gene uncharacterized LOC102548665 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene phosphodiesterase 3B Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-1
    Names
    macropain subunit C2
    multicatalytic endopeptidase complex subunit C2
    proteasome (prosome, macropain) subunit, alpha type 1
    proteasome alpha 1 subunit
    proteasome component C2
    proteasome nu chain
    NP_058974.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017278.1NP_058974.1  proteasome subunit alpha type-1

      See identical proteins and their annotated locations for NP_058974.1

      Status: PROVISIONAL

      Source sequence(s)
      D90265
      UniProtKB/Swiss-Prot
      P18420
      Related
      ENSRNOP00000015946.4, ENSRNOT00000015946.4
      Conserved Domains (1) summary
      cd03749
      Location:6216
      proteasome_alpha_type_1; proteasome_alpha_type_1. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      183733567..183744586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      166294949..166305966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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