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    Rhoc ras homolog family member C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295342, updated on 19-Apr-2019

    Summary

    Official Symbol
    Rhocprovided by RGD
    Official Full Name
    ras homolog family member Cprovided by RGD
    Primary source
    RGD:1304965
    See related
    Ensembl:ENSRNOG00000012630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Kidney (RPKM 358.0), Heart (RPKM 322.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Rhoc in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207271692..207278010)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (226690856..226697174)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1J Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene Wnt family member 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    apical junction assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment or maintenance of actin cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lipase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stereocilium IEA
    Inferred from Electronic Annotation
    more info
     
    stereocilium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    rho-related GTP-binding protein RhoC
    Names
    ras homolog gene family, member C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106461.1NP_001099931.1  rho-related GTP-binding protein RhoC

      See identical proteins and their annotated locations for NP_001099931.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      Related
      ENSRNOP00000017254.3, ENSRNOT00000017254.6
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      207271692..207278010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233074.1XP_006233136.1  rho-related GTP-binding protein RhoC isoform X1

      See identical proteins and their annotated locations for XP_006233136.1

      UniProtKB/TrEMBL
      B2RYP0
      Conserved Domains (2) summary
      smart00174
      Location:8180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      184753781..184759832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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