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    Wwtr1 WW domain containing transcription regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295062, updated on 19-Apr-2019

    Summary

    Official Symbol
    Wwtr1provided by RGD
    Official Full Name
    WW domain containing transcription regulator 1provided by RGD
    Primary source
    RGD:1559609
    See related
    Ensembl:ENSRNOG00000016617
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 216.1), Lung (RPKM 209.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Wwtr1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147577149..147693033, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (166985078..167101346, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350014 Neighboring gene transmembrane 4 L six family member 4 Neighboring gene 60S ribosomal protein L12-like Neighboring gene COMM domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC116096

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    glomerulus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart process IEA
    Inferred from Electronic Annotation
    more info
     
    heart process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hippo signaling IEA
    Inferred from Electronic Annotation
    more info
     
    hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kidney morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mesenchymal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of metanephric nephron tubule epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of metanephric nephron tubule epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell division ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    WW domain-containing transcription regulator protein 1
    Names
    transcriptional co-activator with PDZ-binding motif (TA)Z
    transcriptional co-activator with PDZ-binding motif (TAZ)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024869.1NP_001020040.1  WW domain-containing transcription regulator protein 1

      See identical proteins and their annotated locations for NP_001020040.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097968
      UniProtKB/TrEMBL
      Q4V7E6
      Related
      ENSRNOP00000022507.3, ENSRNOT00000022507.5
      Conserved Domains (1) summary
      smart00456
      Location:125156
      WW; Domain with 2 conserved Trp (W) residues

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      147577149..147693033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      136102030..136217634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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