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    Acta1 actin, alpha 1, skeletal muscle [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29437, updated on 5-May-2019

    Summary

    Official Symbol
    Acta1provided by RGD
    Official Full Name
    actin, alpha 1, skeletal muscleprovided by RGD
    Primary source
    RGD:2025
    See related
    Ensembl:ENSRNOG00000017786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may act as a structural component of the cytoskeleton; may play a role in muscle function [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 144696.8) See more
    Orthologs

    Genomic context

    See Acta1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56674072..56677084, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (67389899..67392911, complement)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene centriole, cilia and spindle-associated protein Neighboring gene uncharacterized LOC108348965 Neighboring gene nucleoporin 133 Neighboring gene ATP binding cassette subfamily B member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesenchyme migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to extracellular stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle fiber adaptation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal muscle thin filament assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    skeletal muscle thin filament assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal muscle thin filament assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sarcomere ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    striated muscle thin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin, alpha skeletal muscle
    Names
    actin alpha 1
    alpha-actin-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019212.2NP_062085.1  actin, alpha skeletal muscle

      See identical proteins and their annotated locations for NP_062085.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061974
      UniProtKB/Swiss-Prot
      P68136
      Related
      ENSRNOP00000024084.3, ENSRNOT00000024084.6
      Conserved Domains (1) summary
      PTZ00281
      Location:4377
      PTZ00281; actin; Provisional

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      56674072..56677084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      51258256..51261324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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