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    Rasgrp1 RAS guanyl releasing protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29434, updated on 18-Apr-2019

    Summary

    Official Symbol
    Rasgrp1provided by RGD
    Official Full Name
    RAS guanyl releasing protein 1provided by RGD
    Primary source
    RGD:3539
    See related
    Ensembl:ENSRNOG00000005404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rasgrp
    Summary
    putative guanine nucleotide exchange factor with Ca2+ and diacylglycerol binding domains; may activate Rap protein mediated inhibition of Ras signaling pathways [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 342.5), Thymus (RPKM 328.1) and 5 other tissues See more
    Orthologs

    Genomic context

    See Rasgrp1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (108984029..109044420, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (115539782..115600270, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene microRNA 674 Neighboring gene family with sequence similarity 98, member B Neighboring gene uncharacterized LOC108350442 Neighboring gene uncharacterized LOC103691867

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rap guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Ras guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    diacylglycerol binding IEA
    Inferred from Electronic Annotation
    more info
     
    diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylcholine binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interferon-gamma secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-gamma secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    secretory granule localization IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAS guanyl-releasing protein 1
    Names
    CalDAG-GEF1
    RAS guanyl releasing protein 1 (calcium and DAG-regulated)
    calDAG-GEFII
    calcium and DAG-regulated guanine nucleotide exchange factor II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019211.2NP_062084.2  RAS guanyl-releasing protein 1

      See identical proteins and their annotated locations for NP_062084.2

      Status: PROVISIONAL

      Source sequence(s)
      AF081196
      UniProtKB/Swiss-Prot
      Q9R1K8
      Related
      ENSRNOP00000007687.4, ENSRNOT00000007687.4
      Conserved Domains (5) summary
      smart00147
      Location:201437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54176
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:474521
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:542591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478526
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      108984029..109044420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      103097991..103157871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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