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    Hells helicase, lymphoid specific [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294071, updated on 18-Apr-2019

    Summary

    Official Symbol
    Hellsprovided by RGD
    Official Full Name
    helicase, lymphoid specificprovided by RGD
    Primary source
    RGD:1309820
    See related
    Ensembl:ENSRNOG00000047104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Thymus (RPKM 136.5), Spleen (RPKM 101.2) and 9 other tissues See more

    Genomic context

    See Hells in Genome Data Viewer
    Location:
    1q53
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (257901856..257953889)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (265357043..265402172)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene cytochrome P450, subfamily 2, polypeptide 11 Neighboring gene lymphoid-specific helicase-like Neighboring gene hypothetical protein LOC685933 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 24 Neighboring gene uncharacterized LOC108349703

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    DNA methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    maintenance of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    methylation-dependent chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pericentric heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    urogenital system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    helicase, lymphoid specific
    Names
    TBC1D12: TBC1 domain family, member 12

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106371.1NP_001099841.1  helicase, lymphoid specific

      See identical proteins and their annotated locations for NP_001099841.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      M0R3Y7
      Related
      ENSRNOP00000064061.1, ENSRNOT00000073015.2
      Conserved Domains (4) summary
      COG0513
      Location:562818
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00046
      Location:242384
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:225576
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:597711
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      257901856..257953889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589048.1XP_017444537.1  helicase, lymphoid specific isoform X1

      UniProtKB/TrEMBL
      M0R3Y7
      Conserved Domains (4) summary
      COG0513
      Location:562818
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00046
      Location:242384
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:225576
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:597711
      Helicase_C; Helicase conserved C-terminal domain
    2. XM_008760366.2XP_008758588.1  helicase, lymphoid specific isoform X2

      See identical proteins and their annotated locations for XP_008758588.1

      Conserved Domains (1) summary
      pfam00271
      Location:192306
      Helicase_C; Helicase conserved C-terminal domain
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