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    Smad2 SMAD family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29357, updated on 26-Mar-2019

    Summary

    Official Symbol
    Smad2provided by RGD
    Official Full Name
    SMAD family member 2provided by RGD
    Primary source
    RGD:3031
    See related
    Ensembl:ENSRNOG00000018140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Madh2
    Summary
    transcriptional mediator for both activin and TGFbeta [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 158.7), Lung (RPKM 157.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Smad2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (72550107..72612078)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (71672879..71735128)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546313 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene uncharacterized LOC108348863 Neighboring gene 60S ribosomal protein L15-like Neighboring gene 28S ribosomal protein S21, mitochondrial-like Neighboring gene uncharacterized LOC103694247

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC156656

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    co-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    primary miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    type I transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SMAD protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adrenal gland development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    anterior/posterior pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    common-partner SMAD protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    common-partner SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cranial skeleton morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic cranial skeleton morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
     
    mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    mesoderm formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nodal signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    paraxial mesoderm morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    paraxial mesoderm morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    pericardium development IEA
    Inferred from Electronic Annotation
    more info
     
    pericardium development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    response to cholesterol IEA
    Inferred from Electronic Annotation
    more info
     
    response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    secondary palate development IEA
    Inferred from Electronic Annotation
    more info
     
    secondary palate development ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    zygotic specification of dorsal/ventral axis IEA
    Inferred from Electronic Annotation
    more info
     
    zygotic specification of dorsal/ventral axis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SMAD protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    activin responsive factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    activin responsive factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    heteromeric SMAD protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 2
    Names
    SMAD 2
    mad-related protein 2
    mothers against DPP homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277450.1NP_001264379.1  mothers against decapentaplegic homolog 2

      See identical proteins and their annotated locations for NP_001264379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AABR07032580, AABR07032581, BC127497
      UniProtKB/Swiss-Prot
      O70436
      Related
      ENSRNOP00000048329.3, ENSRNOT00000046847.4
      Conserved Domains (2) summary
      cd10491
      Location:8172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    2. NM_019191.2NP_062064.1  mothers against decapentaplegic homolog 2

      See identical proteins and their annotated locations for NP_062064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AABR07032580, AABR07032581, AB010147
      UniProtKB/Swiss-Prot
      O70436
      Related
      ENSRNOP00000075341.1, ENSRNOT00000092173.1
      Conserved Domains (2) summary
      cd10491
      Location:8172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      72550107..72612078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254945.3XP_006255007.1  mothers against decapentaplegic homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006255007.1

      Conserved Domains (2) summary
      cd10491
      Location:8142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    2. XM_006254946.3XP_006255008.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0P2
      Related
      ENSRNOP00000071524.1, ENSRNOT00000089468.1
      Conserved Domains (2) summary
      cd10985
      Location:210400
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:53116
      MH1; N-terminal Mad Homology 1 (MH1) domain

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      68381756..68443610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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